General Dosage
200-400mg daily in divided doses
Maximum dose: 400mg daily (higher doses increase GI side effects)
I3C (Indole-3-Carbinol) Dosage Guide
Evidence:Moderate
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Dosage Recommendations
General recommendation: 200-400mg daily in divided doses
Timing: Divided into two doses with meals • Take with food for best absorption.
Dosage by Condition
Estrogen metabolism
200-400mg dailyModerate
Cervical dysplasia support
200-400mg dailyEmerging
General detoxification
200mg dailyPreliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Estrogen metabolism | 200-400mg daily | Moderate |
| Cervical dysplasia support | 200-400mg daily | Emerging |
| General detoxification | 200mg daily | Preliminary |
Upper limit: 400mg daily (higher doses increase GI side effects)
Timing & Absorption
Divided into two doses with meals
Best taken with food for optimal absorption.
References
- RCTBell MC, Crowley-Nowick P, Bradlow HL, Sepkovic DW, Schmidt-Grimminger D, Howell P, Mayeaux EJ, Tucker A, Turbat-Herrera EA, Mathis JM (2000). Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecologic Oncology. DOI PubMed
- RCTReed GA, Arneson DW, Putnam WC, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A (2005). Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. Cancer Epidemiology, Biomarkers & Prevention. DOI PubMed