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Types of I3C (Indole-3-Carbinol): Forms & Bioavailability

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
I3C CapsulesModerate (pH-dependent conversion)General hormonal support — most common supplemental form
I3C + DIM CombinationModerate-HighComprehensive estrogen metabolism support — covers both precursor and active metabolite

I3C Capsules

Bioavailability: Moderate (pH-dependent conversion). Best for: General hormonal support — most common supplemental form.

I3C + DIM Combination

Bioavailability: Moderate-High. Best for: Comprehensive estrogen metabolism support — covers both precursor and active metabolite.

Full I3C (Indole-3-Carbinol) Guide

References

  1. RCTBell MC, Crowley-Nowick P, Bradlow HL, Sepkovic DW, Schmidt-Grimminger D, Howell P, Mayeaux EJ, Tucker A, Turbat-Herrera EA, Mathis JM (2000). Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecologic Oncology. DOI PubMed
  2. RCTReed GA, Arneson DW, Putnam WC, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A (2005). Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. Cancer Epidemiology, Biomarkers & Prevention. DOI PubMed