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L-Glutamine (Gut Health) Dosage Guide

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

5-10g daily in divided doses (2-3 times per day)

Maximum dose: 40g/day used in clinical settings; 20g/day common upper limit for supplements

Dosage Recommendations

General recommendation: 5-10g daily in divided doses (2-3 times per day)

Timing: Divide into 2-3 doses throughout the day; take on an empty stomach for best absorption

Dosage by Condition

ConditionRecommended DoseEvidence
Leaky gut / intestinal permeability5-10g daily in divided dosesModerate
IBD support5-15g dailyEmerging
Post-surgical gut recovery10-20g daily (clinical setting)Moderate

Upper limit: 40g/day used in clinical settings; 20g/day common upper limit for supplements

Timing & Absorption

Divide into 2-3 doses throughout the day; take on an empty stomach for best absorption

Can be taken with or without food.

References

  1. (). Glutamine and the preservation of gut integrity. The Lancet. DOI
  2. (). Glutamine regulates Caco-2 cell tight junction proteins. American Journal of Physiology-Gastrointestinal and Liver Physiology. DOI