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L-Tyrosine Dosage Guide

Evidence:Moderate
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

500-2,000 mg 30-60 minutes before a stressful or demanding task

Maximum dose: 12 g/day (150 mg/kg) has been used in military studies; 2 g/day is typical for supplements

Dosage Recommendations

General recommendation: 500-2,000 mg 30-60 minutes before a stressful or demanding task

Timing: Take 30-60 minutes before demanding tasks on an empty stomach for best brain uptake

Dosage by Condition

Acute stress performance
100-150 mg/kg body weightModerate
Daily nootropic use
500-1,000 mgEmerging
Pre-workout focus
1,000-2,000 mgEmerging

Upper limit: 12 g/day (150 mg/kg) has been used in military studies; 2 g/day is typical for supplements

Timing & Absorption

Take 30-60 minutes before demanding tasks on an empty stomach for best brain uptake

Can be taken with or without food.

Full L-Tyrosine Guide

References

  1. RCTMahoney CR, Castellani J, Kramer FM, et al. (2007). Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior. DOI PubMed
  2. ReviewJongkees BJ, Hommel B, Kühn S, Colzato LS (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands — a review. Journal of Psychiatric Research. DOI PubMed
  3. Diao W, Su D, Cao Y, Jia Z (2022). The diagnostic accuracy of O-(2-18F-fluoroethyl)-L-tyrosine parameters for the differentiation of brain tumour progression from treatment-related changes.. Nuclear medicine communications. DOI PubMed
  4. Spankowsky S, Arlt S, Arndt G, Heuwieser W (2011). [Validity of the use of L-Tyrosine to enhance fertility of female domestic animals. A study on the evidence from the literature].. Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere. PubMed
  5. RCTMcAllister MJ, Martaindale MH, Dillard CC, McCullough R (2024). Impact of L-theanine and L-tyrosine on markers of stress and cognitive performance in response to a virtual reality based active shooter training drill.. Stress (Amsterdam, Netherlands). DOI PubMed
  6. Yang X, He X, Xu S, Zhang Y, et al. (2023). Effect of Lacticaseibacillus paracasei strain Shirota supplementation on clinical responses and gut microbiome in Parkinson's disease.. Food & function. DOI PubMed
  7. Kruszewski M, Merchelski M, Kruszewski A, Tabęcki R, et al. (2022). Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study.. Nutrients. DOI PubMed
Show 5 more references
  1. RCTMathar D, Erfanian Abdoust M, Marrenbach T, Tuzsus D, et al. (2022). The catecholamine precursor Tyrosine reduces autonomic arousal and decreases decision thresholds in reinforcement learning and temporal discounting.. PLoS computational biology. DOI PubMed
  2. Lang JA, Krajek AC, Schwartz KS, Rand JE (2020). Oral L-Tyrosine Supplementation Improves Core Temperature Maintenance in Older Adults.. Medicine and science in sports and exercise. DOI PubMed
  3. RCTLang JA, Smaller KA (2017). Oral l-tyrosine supplementation augments the vasoconstriction response to whole-body cooling in older adults.. Experimental physiology. DOI PubMed
  4. Israely M, Ram A, Brandeis R, Alter Z, et al. (2017). A Double Blind, Randomized Cross-Over Trial of Tyrosine Treatment on Cognitive Function and Psychological Parameters in Severe Hospitalized Anorexia Nervosa Patients.. Israel journal of psychiatry. PubMed
  5. Jung YP, Earnest CP, Koozehchian M, Galvan E, et al. (2017). Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance.. Journal of the International Society of Sports Nutrition. DOI PubMed