Evidence Level
Lion's mane has emerged as a promising natural supplement for cognitive health and neuroprotection. A seminal 2009 study by Mori et al. demonstrated that Hericium erinaceus supplementation significantly improved cognitive function in older adults with mild cognitive impairment over a 16-week period. This was supported by Lai et al. (2013), who identified lion's mane's neurotrophic properties, including its ability to stimulate nerve growth factor (NGF) synthesis in vitro.
Recent research has expanded on these findings. Saitsu et al. (2019) reported that oral intake of Hericium erinaceus improved cognitive function scores in healthy adults, suggesting broader applicability beyond impaired populations. Additionally, a 2023 pilot study by Docherty et al. found that lion's mane supplementation enhanced cognitive speed and reduced stress in young adults after acute and chronic use.
However, not all studies have shown consistent benefits. Surendran et al. (2025) conducted a double-blind RCT with 18 participants and found no significant cognitive or mood improvements from lion's mane extract, though there was some improvement in pegboard test performance. This highlights the need for further research to fully understand its effects across different populations.
Overall, while lion's mane shows promise as a cognitive enhancer and neuroprotective agent, more studies are needed to confirm these benefits and explore potential mechanisms of action.