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Types of Lithium Orotate: Forms & Bioavailability

Evidence:Emerging
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Forms Comparison

FormBioavailabilityBest For
Lithium OrotateModerateMost common OTC form — proposed to cross the blood-brain barrier more efficiently than lithium carbonate at low doses
Lithium AspartateModerateAlternative low-dose form — less commonly available than orotate

Lithium Orotate

Bioavailability: Moderate. Best for: Most common OTC form — proposed to cross the blood-brain barrier more efficiently than lithium carbonate at low doses.

Lithium Aspartate

Bioavailability: Moderate. Best for: Alternative low-dose form — less commonly available than orotate.

References

  1. Vita A, De Peri L, Sacchetti E (2015). Lithium in drinking water and suicide prevention: a review of the evidence. International Clinical Psychopharmacology. DOI PubMed
  2. ObservationalFajardo VA, Fajardo VA, LeBlanc PJ, MacPherson REK (2018). Examining the relationship between trace lithium in drinking water and the rising rates of age-adjusted Alzheimer's disease mortality in Texas. Journal of Alzheimer's Disease. DOI PubMed
  3. ObservationalKessing LV, Gerds TA, Knudsen NN, et al. (2017). Association of lithium in drinking water with the incidence of dementia. JAMA Psychiatry. DOI PubMed