Safety Profile
Overall safety rating: Generally Safe
Magnesium Side Effects & Safety
SC
DJP
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Digestive upset (most common with magnesium oxide and citrate)
- Diarrhea at high doses (especially citrate)
- Nausea when taken on empty stomach
- Very rare: low blood pressure at extremely high doses
Drug & Supplement Interactions
- May reduce absorption of bisphosphonates, antibiotics (tetracyclines, quinolones)
- May interact with blood pressure medications
- Zinc supplements may reduce magnesium absorption at high doses
- Separate from calcium supplements by 2 hours for optimal absorption
Maximum Dose
Do not exceed: 350mg/day from supplements (NIH Upper Tolerable Intake Level)
References
- Boyle NB, Lawton C, Dye L (2017). The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients. DOI PubMed
- Arab A, Rafie N, Amani R, Shirani F (2023). The Role of Magnesium in Sleep Health. Journal of Research in Medical Sciences. DOI PubMed
- Chiu HY, Yeh TH, Huang YC, Chen PY (2016). Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis. Clinical Journal of Pain. DOI PubMed