General Dosage
300-1000mg daily, taken in the morning
Maximum dose: 2000mg/day (doses up to 2000mg have been tested safely in short-term trials)
Nicotinamide Riboside (NR) Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 300-1000mg daily, taken in the morning
Timing: Morning; may cause mild insomnia if taken late in the day
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General NAD+ support | 300mg daily | Moderate |
| Anti-aging / longevity | 500-1000mg daily | Emerging |
| Cardiovascular support | 1000mg daily | Emerging |
Upper limit: 2000mg/day (doses up to 2000mg have been tested safely in short-term trials)
Timing & Absorption
Morning; may cause mild insomnia if taken late in the day
Can be taken with or without food.
References
- Martens CR, Denman BA, Mazzo MR, et al. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. DOI PubMed
- Elhassan YS, Kluckova K, Fletcher RS, et al. (2019). Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures. Cell Reports. DOI PubMed
- Trammell SAJ, Schmidt MS, Weidemann BJ, et al. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. DOI PubMed