Phosphatidylserine Research & Evidence

SupplementScience.ai Editorial Team·Evidence-Based Supplement Research

Published Mar 11, 2026

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Evidence Level

Moderate

Phosphatidylserine has a solid evidence base for cognitive support in aging populations. The FDA issued a qualified health claim in 2003 acknowledging that PS may reduce the risk of cognitive dysfunction in the elderly. Kato-Kataoka et al. (2010) demonstrated memory improvements in a 6-month RCT. Earlier bovine-derived PS studies (Crook et al., 1991) showed significant cognitive benefits, and soy-derived PS has been confirmed to have comparable efficacy. Monteleone et al. (1992) established the cortisol-blunting effect that makes PS valuable for stress management.

Evidence by Condition

Condition	Studied Dose	Evidence
Memory support	100-300mg daily	Moderate
Cortisol reduction	400-600mg daily	Moderate
ADHD (adjunct)	200mg daily	Emerging

Full Phosphatidylserine Guide

References

Kato-Kataoka A, Sakai M, Ebina R, et al. (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of Clinical Biochemistry and Nutrition. DOI PubMed
Monteleone P, Beinat L, Tanzillo C, et al. (1992). Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. DOI PubMed
Baumeister J, Barthel T, Geiss KR, Weiss M (2008). Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutritional Neuroscience. DOI PubMed