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Plant Sterols / Stanols Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

2-3g plant sterols/stanols daily, divided across meals

Maximum dose: 3g/day (no additional benefit above 3g)

Dosage Recommendations

General recommendation: 2-3g plant sterols/stanols daily, divided across meals

Timing: Divide across 2-3 meals for optimal cholesterol-blocking effect • Take with food for best absorption.

Dosage by Condition

Elevated LDL cholesterol
2-3g daily with mealsStrong
Statin adjunct
2g daily alongside statin therapyStrong
Familial hypercholesterolemia
2-3g daily (adjunct to medication)Moderate

Upper limit: 3g/day (no additional benefit above 3g)

Timing & Absorption

Divide across 2-3 meals for optimal cholesterol-blocking effect

Best taken with food for optimal absorption.

Full Plant Sterols / Stanols Guide

References

  1. Meta-analysisRas RT, Geleijnse JM, Trautwein EA (2014). LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. British Journal of Nutrition. DOI PubMed
  2. Meta-analysisAbumweis SS, Barake R, Jones PJ (2008). Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials. Food & Nutrition Research. DOI PubMed
  3. Malhotra A, Shafiq N, Arora A, Singh M, et al. (2014). Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia.. The Cochrane database of systematic reviews. DOI PubMed
  4. Meta-analysisAmir Shaghaghi M, Abumweis SS, Jones PJH (2013). Cholesterol-lowering efficacy of plant sterols/stanols provided in capsule and tablet formats: results of a systematic review and meta-analysis.. Journal of the Academy of Nutrition and Dietetics. DOI PubMed
  5. Fogacci F, ALGhasab NS, Di Micoli V, Giovannini M, et al. (2024). Cholesterol-Lowering Bioactive Foods and Nutraceuticals in Pediatrics: Clinical Evidence of Efficacy and Safety.. Nutrients. DOI PubMed
  6. ReviewBarkas F, Bathrellou E, Nomikos T, Panagiotakos D, et al. (2023). Plant Sterols and Plant Stanols in Cholesterol Management and Cardiovascular Prevention.. Nutrients. DOI PubMed
  7. Abumweis S, Alzyoud L, Alqadi S (2023). Apolipoprotein E Genetic Variant and Blood Lipid Responses to Plant Sterols: A Systematic Review and Pooled Analysis of Clinical Trials.. Preventive nutrition and food science. DOI PubMed
Show 5 more references
  1. Osadnik T, Goławski M, Lewandowski P, Morze J, et al. (2022). A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults.. Pharmacological research. DOI PubMed
  2. Barkas F, Nomikos T, Liberopoulos E, Panagiotakos D (2020). Diet and Cardiovascular Disease Risk Among Individuals with Familial Hypercholesterolemia: Systematic Review and Meta-Analysis.. Nutrients. DOI PubMed
  3. RCTMcKenney JM, Jenks BH, Shneyvas E, Brooks JR, et al. (2014). A softgel dietary supplement containing esterified plant sterols and stanols improves the blood lipid profile of adults with primary hypercholesterolemia: a randomized, double-blind, placebo-controlled replication study.. Journal of the Academy of Nutrition and Dietetics. DOI PubMed
  4. Maki KC, Lawless AL, Reeves MS, Kelley KM, et al. (2013). Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia.. Nutrition (Burbank, Los Angeles County, Calif.). DOI PubMed
  5. Maki KC, Lawless AL, Reeves MS, Dicklin MR, et al. (2012). Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial.. International journal of food sciences and nutrition. DOI PubMed