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Pterostilbene Dosage Guide

Evidence:Emerging
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

50-250mg daily

Maximum dose: 250mg/day (limited safety data above this dose in humans)

Dosage Recommendations

General recommendation: 50-250mg daily

Timing: With or without food; can be taken morning or evening

Dosage by Condition

General longevity / sirtuin activation
50-150mg dailyEmerging
Blood pressure support
125mg 2x dailyEmerging
Cognitive support
50-100mg dailyPreliminary

Upper limit: 250mg/day (limited safety data above this dose in humans)

Timing & Absorption

With or without food; can be taken morning or evening

Can be taken with or without food.

Full Pterostilbene Guide

References

  1. RCTRiche DM, McEwen CL, Riche KD, et al. (2013). Analysis of safety from a human clinical trial with pterostilbene. Journal of Toxicology. DOI PubMed
  2. ReviewBuehrer BS, Grden AR, Johnson E, Patel MY, et al. (2026). Pterostilbene in the Management and Treatment of Multiple Myeloma.. Current issues in molecular biology. DOI PubMed
  3. RCTDellinger RW, Holmes HE, Hu-Seliger T, Butt RW, et al. (2023). Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial.. Hepatology (Baltimore, Md.). DOI PubMed
  4. RCTCarrera-Juliá S, Estrela JM, Zacarés M, Navarro MÁ, et al. (2023). Effect of the Mediterranean diet supplemented with nicotinamide riboside and pterostilbene and/or coconut oil on anthropometric variables in amyotrophic lateral sclerosis. A pilot study.. Frontiers in nutrition. DOI PubMed
  5. RCTMajeed M, Nagabhushanam K, Paulose S, Mundkur L (2023). A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.. Journal of evidence-based integrative medicine. DOI PubMed
  6. RCTJensen JB, Dollerup OL, Møller AB, Billeskov TB, et al. (2022). A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.. JCI insight. DOI PubMed
  7. RCTDellinger RW, Santos SR, Morris M, Evans M, et al. (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study.. NPJ aging and mechanisms of disease. DOI PubMed
Show 5 more references
  1. RCTJoy JM, Vogel RM, Moon JR, Falcone PH, et al. (2016). Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men.. Journal of the International Society of Sports Nutrition. DOI PubMed
  2. RCTQureshi AA, Khan DA, Mahjabeen W, Papasian CJ, et al. (2013). Nutritional Supplement-5 with a Combination of Proteasome Inhibitors (Resveratrol, Quercetin, δ-Tocotrienol) Modulate Age-Associated Biomarkers and Cardiovascular Lipid Parameters in Human Subjects.. Journal of clinical & experimental cardiology. DOI PubMed
  3. RCTHougee S, Faber J, Sanders A, de Jong RB, et al. (2005). Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers.. Planta medica. DOI PubMed
  4. ObservationalKapetanovic IM, Muzzio M, Huang Z, et al. (2011). Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemotherapy and Pharmacology. DOI PubMed
  5. ObservationalChang J, Rimando A, Pallas M, et al. (2012). Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of Aging. DOI PubMed