Safety Profile
Overall safety rating: Generally Safe
Pterostilbene Side Effects & Safety
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Potential Side Effects
- Well-tolerated in clinical trials at doses up to 250mg/day
- May increase LDL cholesterol at higher doses (250mg 2x daily) in some individuals (Riche et al., 2014)
- Mild GI discomfort reported infrequently
- Limited long-term human safety data
Drug & Supplement Interactions
- Blood thinners — may inhibit platelet aggregation similarly to resveratrol
- CYP1A2 substrates — pterostilbene may modestly inhibit this enzyme
- Blood pressure medications — additive hypotensive effects possible
Maximum Dose
Do not exceed: 250mg/day (limited safety data above this dose in humans)
References
- Riche DM, McEwen CL, Riche KD, et al. (2013). Analysis of safety from a human clinical trial with pterostilbene. Journal of Toxicology. DOI PubMed
- Kapetanovic IM, Muzzio M, Huang Z, et al. (2011). Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemotherapy and Pharmacology. DOI PubMed
- Chang J, Rimando A, Pallas M, et al. (2012). Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of Aging. DOI PubMed