Safety Profile
Overall safety rating: Generally Safe
Pterostilbene Side Effects & Safety
Evidence:Emerging
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Potential Side Effects
- Well-tolerated in clinical trials at doses up to 250mg/day
- May increase LDL cholesterol at higher doses (250mg 2x daily) in some individuals (Riche et al., 2014)
- Mild GI discomfort reported infrequently
- Limited long-term human safety data
Drug & Supplement Interactions
- Blood thinners — may inhibit platelet aggregation similarly to resveratrol
- CYP1A2 substrates — pterostilbene may modestly inhibit this enzyme
- Blood pressure medications — additive hypotensive effects possible
Maximum Dose
Do not exceed: 250mg/day (limited safety data above this dose in humans)
References
- RCTRiche DM, McEwen CL, Riche KD, et al. (2013). Analysis of safety from a human clinical trial with pterostilbene. Journal of Toxicology. DOI PubMed
- ReviewBuehrer BS, Grden AR, Johnson E, Patel MY, et al. (2026). Pterostilbene in the Management and Treatment of Multiple Myeloma.. Current issues in molecular biology. DOI PubMed
- RCTDellinger RW, Holmes HE, Hu-Seliger T, Butt RW, et al. (2023). Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial.. Hepatology (Baltimore, Md.). DOI PubMed
- RCTCarrera-Juliá S, Estrela JM, Zacarés M, Navarro MÁ, et al. (2023). Effect of the Mediterranean diet supplemented with nicotinamide riboside and pterostilbene and/or coconut oil on anthropometric variables in amyotrophic lateral sclerosis. A pilot study.. Frontiers in nutrition. DOI PubMed
- RCTMajeed M, Nagabhushanam K, Paulose S, Mundkur L (2023). A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.. Journal of evidence-based integrative medicine. DOI PubMed
- RCTJensen JB, Dollerup OL, Møller AB, Billeskov TB, et al. (2022). A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.. JCI insight. DOI PubMed
- RCTDellinger RW, Santos SR, Morris M, Evans M, et al. (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study.. NPJ aging and mechanisms of disease. DOI PubMed
Show 5 more references
- RCTJoy JM, Vogel RM, Moon JR, Falcone PH, et al. (2016). Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men.. Journal of the International Society of Sports Nutrition. DOI PubMed
- RCTQureshi AA, Khan DA, Mahjabeen W, Papasian CJ, et al. (2013). Nutritional Supplement-5 with a Combination of Proteasome Inhibitors (Resveratrol, Quercetin, δ-Tocotrienol) Modulate Age-Associated Biomarkers and Cardiovascular Lipid Parameters in Human Subjects.. Journal of clinical & experimental cardiology. DOI PubMed
- RCTHougee S, Faber J, Sanders A, de Jong RB, et al. (2005). Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers.. Planta medica. DOI PubMed
- ObservationalKapetanovic IM, Muzzio M, Huang Z, et al. (2011). Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemotherapy and Pharmacology. DOI PubMed
- ObservationalChang J, Rimando A, Pallas M, et al. (2012). Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of Aging. DOI PubMed