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SupplementScience

Reishi Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Safe with Caution

Potential Side Effects

  • Mild digestive upset (nausea, bloating) in some users
  • Dry mouth and throat
  • Dizziness or headache (uncommon)
  • Rare: liver toxicity reported with concentrated reishi powders (case reports)
  • Nosebleeds or blood-thinning effects at high doses

Drug & Supplement Interactions

  • May enhance effects of anticoagulant/antiplatelet medications (reishi inhibits platelet aggregation)
  • May lower blood pressure — caution with antihypertensive medications
  • May interact with immunosuppressant drugs (stimulates immune function)
  • May lower blood sugar — monitor with diabetes medications
  • Discontinue 2 weeks before surgery due to blood-thinning effects

Maximum Dose

Do not exceed: 5.4g extract daily (highest dose used in clinical trials)

References

  1. (). Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database of Systematic Reviews. DOI
  2. (). Extract of Ganoderma lucidum prolongs sleep time in rats. Journal of Ethnopharmacology. DOI