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Rhodiola Rosea Research & Evidence

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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Evidence Level

Moderate

Rhodiola Rosea has been studied in several randomized controlled trials (RCTs) and smaller clinical studies, with a growing body of evidence supporting its use for managing stress-related fatigue and enhancing cognitive performance. Research typically uses extracts standardized to 3% rosavins and 1% salidroside, with doses ranging from 200-600mg daily. A notable multicenter RCT (n=161) demonstrated significant reductions in fatigue and improvements in memory and associative thinking during stressful conditions compared to placebo. While more research is needed for long-term effects and broader applications, the existing evidence suggests moderate efficacy for stress-related fatigue and cognitive support under acute stress.

Evidence by Condition

ConditionStudied DoseEvidence
Stress-related fatigue200-600mg dailyStrong
Cognitive performance under stress200-600mg dailyStrong

Related Research Summaries

Rhodiola Rosea for Stress-Related Fatigue: Multicenter RCT
rct · 161 participants
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References

  1. ReviewLu Y, Deng B, Xu L, Liu H, et al. (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review.. Frontiers in nutrition. DOI PubMed
  2. ReviewTinsley GM, Jagim AR, Potter GDM, Garner D, et al. (2024). Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature.. The British journal of nutrition. DOI PubMed
  3. RCTSchwarz NA, Stratton MT, Colquhoun RJ, Manganti AM, et al. (2024). Salidroside and exercise performance in healthy active young adults - an exploratory, randomized, double-blind, placebo-controlled study.. Journal of the International Society of Sports Nutrition. DOI PubMed
  4. Meta-analysisUrata M, Sakurai H, Ueno F, Maruki T, et al. (2025). Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.. Neuropsychopharmacology reports. DOI PubMed
  5. RCTLara PM, Vera J, Marcos-Frutos D, Alix-Fages C, et al. (2025). Can Rhodiola rosea supplementation mitigate digital eye strain? A triple-blinded placebo-controlled study.. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). DOI PubMed