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Rhodiola Rosea Side Effects & Safety

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Safe with Caution

Potential Side Effects

  • Gastrointestinal upset (e.g., nausea, diarrhea)
  • Headache or dizziness
  • Insomnia or difficulty sleeping (especially if taken in the evening)
  • Increased heart rate or palpitations (especially at higher doses)

Drug & Supplement Interactions

  • Rhodiola Rosea may interact with steroid hormones by modulating cortisol levels, potentially affecting the efficacy of corticosteroid medications.
  • It can interact with antidepressants, particularly SSRIs, as both influence serotonin pathways and mood regulation.
  • Rhodiola Rosea may interact with blood pressure medications by influencing blood pressure regulation mechanisms.

Maximum Dose

Do not exceed: 600mg/day (based on standard recommendations)

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References

  1. ReviewLu Y, Deng B, Xu L, Liu H, et al. (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review.. Frontiers in nutrition. DOI PubMed
  2. ReviewTinsley GM, Jagim AR, Potter GDM, Garner D, et al. (2024). Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature.. The British journal of nutrition. DOI PubMed
  3. RCTSchwarz NA, Stratton MT, Colquhoun RJ, Manganti AM, et al. (2024). Salidroside and exercise performance in healthy active young adults - an exploratory, randomized, double-blind, placebo-controlled study.. Journal of the International Society of Sports Nutrition. DOI PubMed
  4. Meta-analysisUrata M, Sakurai H, Ueno F, Maruki T, et al. (2025). Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.. Neuropsychopharmacology reports. DOI PubMed
  5. RCTLara PM, Vera J, Marcos-Frutos D, Alix-Fages C, et al. (2025). Can Rhodiola rosea supplementation mitigate digital eye strain? A triple-blinded placebo-controlled study.. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). DOI PubMed