General Dosage
600-1,200mg daily in divided doses, taken on an empty stomach
Maximum dose: 1,600mg daily has been used in depression trials without significant safety concerns; 1,200mg is typical for OA
SAMe (S-Adenosyl Methionine) Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 600-1,200mg daily in divided doses, taken on an empty stomach
Timing: Take on an empty stomach 30 minutes before meals; divide into 2-3 doses throughout the day for best absorption
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Knee osteoarthritis | 600-1,200mg daily in 2-3 divided doses | Strong |
| Hip osteoarthritis | 600-1,200mg daily | Moderate |
| OA with comorbid depression | 1,200mg daily | Moderate |
Upper limit: 1,600mg daily has been used in depression trials without significant safety concerns; 1,200mg is typical for OA
Timing & Absorption
Take on an empty stomach 30 minutes before meals; divide into 2-3 doses throughout the day for best absorption
Can be taken with or without food.
References
- Soeken KL, Lee WL, Bausell RB, et al. (2002). Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. Journal of Family Practice. PubMed
- Najm WI, Reinsch S, Hoehler F, et al. (2004). S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. BMC Musculoskeletal Disorders. DOI PubMed
- Kim J, Lee EY, Koh EM, et al. (2009). Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis. Journal of Korean Medical Science. DOI PubMed
- Hardy ML, Coulter I, Morton SC, et al. (2003). S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Evidence Report/Technology Assessment (AHRQ). PubMed