Skip to main content
Supplement ScienceSupplementScience

SAMe (S-Adenosyl Methionine) Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

600-1,200mg daily in divided doses, taken on an empty stomach

Maximum dose: 1,600mg daily has been used in depression trials without significant safety concerns; 1,200mg is typical for OA

Dosage Recommendations

General recommendation: 600-1,200mg daily in divided doses, taken on an empty stomach

Timing: Take on an empty stomach 30 minutes before meals; divide into 2-3 doses throughout the day for best absorption

Dosage by Condition

Knee osteoarthritis
600-1,200mg daily in 2-3 divided dosesStrong
Hip osteoarthritis
600-1,200mg dailyModerate
OA with comorbid depression
1,200mg dailyModerate

Upper limit: 1,600mg daily has been used in depression trials without significant safety concerns; 1,200mg is typical for OA

Timing & Absorption

Take on an empty stomach 30 minutes before meals; divide into 2-3 doses throughout the day for best absorption

Can be taken with or without food.

Full SAMe (S-Adenosyl Methionine) Guide

References

  1. Meta-analysisSoeken KL, Lee WL, Bausell RB, et al. (2002). Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. Journal of Family Practice. PubMed
  2. RCTNajm WI, Reinsch S, Hoehler F, et al. (2004). S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. BMC Musculoskeletal Disorders. DOI PubMed
  3. RCTKim J, Lee EY, Koh EM, et al. (2009). Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis. Journal of Korean Medical Science. DOI PubMed
  4. ReviewHardy ML, Coulter I, Morton SC, et al. (2003). S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Evidence Report/Technology Assessment (AHRQ). PubMed