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Types of Strontium: Forms & Bioavailability

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest ForElemental Content
Strontium CitrateModerateOTC bone support — most commonly available supplement form33% elemental strontium by weight
Strontium Ranelate (Protelos)ModeratePrescription-only (Europe) — best-studied form with large RCT evidence for fracture reduction34% elemental strontium by weight
Strontium ChlorideModerateUsed in some supplements and toothpaste for tooth sensitivity

Strontium Citrate

Bioavailability: Moderate. Best for: OTC bone support — most commonly available supplement form. Elemental content: 33% elemental strontium by weight.

Strontium Ranelate (Protelos)

Bioavailability: Moderate. Best for: Prescription-only (Europe) — best-studied form with large RCT evidence for fracture reduction. Elemental content: 34% elemental strontium by weight.

Strontium Chloride

Bioavailability: Moderate. Best for: Used in some supplements and toothpaste for tooth sensitivity.

Full Strontium Guide

References

  1. RCTMeunier PJ, Roux C, Seeman E, et al. (2004). The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. New England Journal of Medicine. DOI PubMed
  2. Reginster JY, Kaufman JM, Goemaere S, et al. (2012). Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. Osteoporosis International. DOI PubMed
  3. Yan MD, Ou YJ, Lin YJ, Liu RM, et al. (2022). Does the incorporation of strontium into calcium phosphate improve bone repair? A meta-analysis.. BMC oral health. DOI PubMed
  4. Hu Z, Tian Y, Li W, Ruan Y, et al. (2020). The efficacy and safety of zoledronic acid and strontium-89 in treating non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials.. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. DOI PubMed
  5. Penrose B, Beresford NA, Broadley MR, Crout NMJ (2015). Inter-varietal variation in caesium and strontium uptake by plants: a meta-analysis.. Journal of environmental radioactivity. DOI PubMed
  6. Meta-analysisKanis JA, Johansson H, Oden A, McCloskey EV (2011). A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX(®).. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. DOI PubMed
  7. RCTBruyère O, Collette J, Rizzoli R, Decock C, et al. (2010). Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years.. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. DOI PubMed
Show 3 more references
  1. ObservationalRabenda V, Reginster JY (2010). Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures.. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. DOI PubMed
  2. Collette J, Bruyère O, Kaufman JM, Lorenc R, et al. (2010). Vertebral anti-fracture efficacy of strontium ranelate according to pre-treatment bone turnover.. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. DOI PubMed
  3. Meta-analysisO'Donnell S, Cranney A, Wells GA, Adachi JD, et al. (2006). Strontium ranelate for preventing and treating postmenopausal osteoporosis.. The Cochrane database of systematic reviews. DOI PubMed