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Tributyrin Dosage Guide

Evidence:Moderate
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

300-1000mg tributyrin daily, taken with meals

Maximum dose: 1500mg/day (higher doses not well-studied)

Dosage Recommendations

General recommendation: 300-1000mg tributyrin daily, taken with meals

Timing: With meals to improve absorption and reduce any GI discomfort • Take with food for best absorption.

Dosage by Condition

General gut health
300-500mg tributyrin dailyModerate
Gut barrier support
500-1000mg tributyrin dailyModerate
Post-antibiotic recovery
500mg tributyrin daily for 4-8 weeksEmerging

Upper limit: 1500mg/day (higher doses not well-studied)

Timing & Absorption

With meals to improve absorption and reduce any GI discomfort

Best taken with food for optimal absorption.

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References

  1. ReviewCanani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A (2011). Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World Journal of Gastroenterology. DOI PubMed
  2. ReviewLiu H, Wang J, He T, Becker S, Zhang G, Li D, Ma X (2018). Butyrate: A Double-Edged Sword for Health?. Advances in Nutrition. DOI PubMed
  3. ObservationalDonohoe DR, Garge N, Zhang X, Sun W, O'Connell TM, Bunger MK, Bultman SJ (2011). The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metabolism. DOI PubMed
  4. RCTCoelho FA, Mezzina ALB, de Oliveira ACR, Alves LKS, et al. (2025). Supplementation with Tributyrin for Gestating Sows Reduces Stillborn Rate and Increases Litter Birth Weight.. Veterinary sciences. DOI PubMed
  5. RCTDang X, Lee H, Lee SJ, Song JH, et al. (2023). Tributyrin and anise mixture supplementation improves growth performance, nutrient digestibility, jejunal villus height, and fecal microbiota in weaned pigs.. Frontiers in veterinary science. DOI PubMed
  6. RCTvan Deuren T, Smolders L, Hartog A, Bouwman FG, et al. (2022). Butyrate and hexanoate-enriched triglycerides increase postprandrial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial.. Frontiers in nutrition. DOI PubMed
  7. RCTPearce CB, Sadek SA, Walters AM, Goggin PM, et al. (2006). A double-blind, randomised, controlled trial to study the effects of an enteral feed supplemented with glutamine, arginine, and omega-3 fatty acid in predicted acute severe pancreatitis.. JOP : Journal of the pancreas. PubMed