General Dosage
300-1000mg tributyrin daily, taken with meals
Maximum dose: 1500mg/day (higher doses not well-studied)
Tributyrin Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 300-1000mg tributyrin daily, taken with meals
Timing: With meals to improve absorption and reduce any GI discomfort • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General gut health | 300-500mg tributyrin daily | Moderate |
| Gut barrier support | 500-1000mg tributyrin daily | Moderate |
| Post-antibiotic recovery | 500mg tributyrin daily for 4-8 weeks | Emerging |
Upper limit: 1500mg/day (higher doses not well-studied)
Timing & Absorption
With meals to improve absorption and reduce any GI discomfort
Best taken with food for optimal absorption.
References
- Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A (2011). Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World Journal of Gastroenterology. DOI PubMed
- Liu H, Wang J, He T, Becker S, Zhang G, Li D, Ma X (2018). Butyrate: A Double-Edged Sword for Health?. Advances in Nutrition. DOI PubMed
- Donohoe DR, Garge N, Zhang X, Sun W, O'Connell TM, Bunger MK, Bultman SJ (2011). The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metabolism. DOI PubMed