Safety Profile
Overall safety rating: Generally Safe
Tributyrin Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Mild GI discomfort during initial use (bloating, gas)
- Loose stools at higher doses
- Unpleasant taste or burping with sodium butyrate forms (less common with tributyrin)
- Rare: headache or nausea
Drug & Supplement Interactions
- No significant drug interactions reported for tributyrin at standard doses
- May enhance effects of anti-inflammatory medications in the GI tract
- Theoretical interaction with HDAC inhibitor drugs used in oncology — consult physician if on cancer treatment
Maximum Dose
Do not exceed: 1500mg/day (higher doses not well-studied)
References
- Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A (2011). Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World Journal of Gastroenterology. DOI PubMed
- Liu H, Wang J, He T, Becker S, Zhang G, Li D, Ma X (2018). Butyrate: A Double-Edged Sword for Health?. Advances in Nutrition. DOI PubMed
- Donohoe DR, Garge N, Zhang X, Sun W, O'Connell TM, Bunger MK, Bultman SJ (2011). The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metabolism. DOI PubMed