We evaluated the growing tributyrin and butyrate supplement market to identify the best options for gut barrier support. Tributyrin is the preferred delivery form because it survives stomach acid and releases butyrate in the colon, where it actually benefits colonocytes.
Best Tributyrin Supplements (2026)
· Updated April 2026
Evidence Ranked
·
2,600+Clinical Studies Cited
·4Tributyrin products evaluated
This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer
As an Amazon Associate, we earn from qualifying purchases. Some links below are affiliate links — this doesn't affect our editorial independence or product ratings. How we evaluate products
Our Verdict
The best tributyrin supplement delivers 300-1000mg tributyrin per serving in an enteric or lipid-coated capsule for targeted colon delivery, with third-party testing for purity.
Best By Category
The best tributyrin supplement is a coated capsule delivering 300-1000mg tributyrin per serving, designed to release...
The best tributyrin supplement is a coated capsule delivering 300-1000mg tributyrin per serving, designed to release butyrate in the intestines rather than the stomach. Look for products that specify tributyrin (not sodium butyrate) and provide third-party testing for purity.
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How We Chose These Products
Products are ranked using our published scoring methodology — evidence strength, dose adequacy, ingredient form, third-party testing signals, value, and clean-label factors are weighted across the 5 criteria below. Commercial relationships do not determine our editorial rankings.
Butyrate Delivery Form
30%Tributyrin delivers butyrate to the colon where it benefits colonocytes. Sodium butyrate releases prematurely in the stomach. We strongly favor tributyrin-based products.
Dose Adequacy
25%Does the product provide a meaningful dose of tributyrin or butyrate per serving? Clinical relevance starts at 300mg tributyrin.
Third-Party Testing
20%Purity testing is important since butyrate supplements can contain impurities. NSF, USP, or independent lab verification is preferred.
Value
15%Cost per serving adjusted for form quality. A $0.80/serving tributyrin delivers more benefit than a $0.30/serving sodium butyrate.
User Experience
10%Smell, taste, capsule size, and GI tolerance. Tributyrin is far superior to sodium butyrate for odor and taste.
#1 Top Pick
Butyrate
BodyBio
3,080 Amazon reviews
9/10
4.3
The most established butyrate supplement brand with thousands of positive reviews. Uses calcium/magnesium butyrate for slightly delayed release compared to sodium butyrate. Provides a meaningful 600mg butyrate dose per serving. Well-regarded by functional medicine practitioners.
IngredientCalcium/Magnesium Butyrate
Dose600mg butyrate (as calcium/magnesium salt)
FormCapsule
TestingThird-Party Tested
600mg butyrate (as calcium/magnesium salt)Clinical range: 300-1000mg tributyrin daily
Therapeutic dose
$1.27/serving$75.99 · 60 Capsules
Pros
- Most established butyrate brand
- 600mg meaningful butyrate dose
- Mineral-buffered for gentler release
Cons
- Not tributyrin form (butyrate salt)
- Some odor when opening bottle
Gluten-freeNon-GMODairy-free
Quick Comparison
#1BodyBio Butyrate
9/10
BodyBio
#1 Top Pick
3,080 Amazon reviews
Best for: Overall gut health with mineral-buffered butyrate
Calcium/Magnesium Butyrate · 600mg butyrate (as calcium/magnesium salt)
Capsule · Third-Party Tested
$75.99
$1.27/serving
#2ProButyrate
8.3/10
Tesseract Medical Research
703 Amazon reviews
Best for: Budget tributyrin option with patented delivery
Tributyrin (CyLoc delivery) · 300mg tributyrin per capsule
Capsule · Third-Party Tested
$58.00
$0.64/serving
#3Sunbutyrate Liquid Butyrate
8/10
Pure Encapsulations
139 Amazon reviews
Best for: Higher-dose tributyrin in flexible liquid form
Tributyrin (liquid form) · 750mg tributyrin per serving
Liquid · Third-Party Tested
$42.50
$1.06/serving
#4Peak Performance CoreBiome Tributyrin
7.8/10
Peak Performance
255 Amazon reviews
Best for: Patented CoreBiome tributyrin in an allergy-friendly formula
CoreBiome Tributyrin (55% Extract) · CoreBiome tributyrin, 2 capsules per serving
Capsule · GMP Certified
$35.95
$1.20/serving
| # | Product | Best For | Ingredient & Dose | Form & Testing | Price | Rating | |
|---|---|---|---|---|---|---|---|
| 1 | BodyBio Butyrate #1 Top Pick 3,080 Amazon reviews | Overall gut health with mineral-buffered butyrate | Calcium/Magnesium Butyrate 600mg butyrate (as calcium/magnesium salt) | Capsule 60 Capsules Third-Party Tested | $75.99 $1.27/serving | 9/10 | |
| 2 | ProButyrate 703 Amazon reviews | Budget tributyrin option with patented delivery | Tributyrin (CyLoc delivery) 300mg tributyrin per capsule | Capsule 120 Capsules Third-Party Tested | $58.00 $0.64/serving | 8.3/10 | |
| 3 | Sunbutyrate Liquid Butyrate 139 Amazon reviews | Higher-dose tributyrin in flexible liquid form | Tributyrin (liquid form) 750mg tributyrin per serving | Liquid 34 Servings Third-Party Tested | $42.50 $1.06/serving | 8/10 | |
| 4 | Peak Performance CoreBiome Tributyrin 255 Amazon reviews | Patented CoreBiome tributyrin in an allergy-friendly formula | CoreBiome Tributyrin (55% Extract) CoreBiome tributyrin, 2 capsules per serving | Capsule 60 Capsules GMP Certified | $35.95 $1.20/serving | 7.8/10 |
Detailed Reviews
#1 Top Pick
BodyBio Butyrate - Postbiotic for Gut Health, Digestive Support, Bloat, Gas & Constipation Relief, Leaky Gut Repair - Calcium, Magnesium + Butyric Acid Supplement for GI Wellness
BodyBio
3,080 Amazon reviews
9/10
(3,080)
Gluten-freeNon-GMODairy-free
The most established butyrate supplement brand with thousands of positive reviews. Uses calcium/magnesium butyrate for slightly delayed release compared to sodium butyrate. Provides a meaningful 600mg butyrate dose per serving. Well-regarded by functional medicine practitioners.
IngredientCalcium/Magnesium Butyrate
Dose600mg butyrate (as calcium/magnesium salt)
FormCapsule
TestingThird-Party Tested
600mg butyrate (as calcium/magnesium salt)Clinical range: 300-1000mg tributyrin daily
Therapeutic dose
$1.27/serving$75.99 · 60 Capsules
Ideal for: Overall gut health with mineral-buffered butyrate
Not ideal for: Those needing true tributyrin for targeted colonic delivery
Pros
- Most established butyrate brand
- 600mg meaningful butyrate dose
- Mineral-buffered for gentler release
- Thousands of positive reviews
Cons
- Not tributyrin form (butyrate salt)
- Some odor when opening bottle
- Larger capsule size
Tesseract Medical Research ProButyrate Gut Health Supplement, Butyric Acid Complex, Gastrointestinal Support Supplement, Helps Restore Balance to Stabilize Gut Microbiome, 600mg (120 Capsules)
Tesseract Medical Research
703 Amazon reviews
8.3/10
(703)
Gluten-freeNon-GMOVegan
Uses CyLoc delivery technology designed to protect tributyrin through stomach acid. Good value at $0.43/serving. Clean formulation focused purely on tributyrin delivery without unnecessary additives.
IngredientTributyrin (CyLoc delivery)
Dose300mg tributyrin per capsule
FormCapsule
TestingThird-Party Tested
300mg tributyrin per capsuleClinical range: 300-1000mg tributyrin daily
Therapeutic dose
$0.64/serving$58.00 · 120 Capsules
Ideal for: Budget tributyrin option with patented delivery
Not ideal for: Those wanting a full therapeutic dose in a single capsule
Pros
- Patented CyLoc delivery technology
- Best value tributyrin option
- Clean focused formula
- True tributyrin form
Cons
- Lower dose per capsule (300mg)
- Less established brand
- May need 2 capsules for full effect
Pure Encapsulations SunButyrate-TG Liquid | Helps Promote Gut Cell Function | 9.5 fl. oz.
Pure Encapsulations
139 Amazon reviews
8/10
(139)
Gluten-freeNon-GMO
Highest tributyrin dose on our list at 750mg per serving. Liquid form allows flexible dosing. Pure tributyrin without fillers or additional ingredients. Good option for those who prefer liquid over capsules.
IngredientTributyrin (liquid form)
Dose750mg tributyrin per serving
FormLiquid
TestingThird-Party Tested
750mg tributyrin per servingClinical range: 300-1000mg tributyrin daily
Therapeutic dose
$1.06/serving$42.50 · 34 Servings
Ideal for: Higher-dose tributyrin in flexible liquid form
Not ideal for: Those sensitive to oily taste or without refrigerator access
Pros
- Highest tributyrin dose (750mg)
- Flexible liquid dosing
- Pure formula
- True tributyrin delivery
Cons
- Mild oily taste
- Requires refrigeration
- Premium price
CoreBiome Tributyrin Postbiotic Supplement Clinically Tested for Gut Health. More Effective Than Sodium Butyrate Capsules. High Bioavailability Post Biotics for Digestive, Leaky Gut, Colon, Microbiome
Peak Performance
255 Amazon reviews
7.8/10
(255)
Gluten-free
Built around patented CoreBiome tributyrin, a clinically studied postbiotic shown to support butyrate-producing gut bacteria such as F. prausnitzii. Free of gluten and the major allergens, GMP-certified, and made in the USA. Each purchase funds a Vitamin Angels donation.
IngredientCoreBiome Tributyrin (55% Extract)
DoseCoreBiome tributyrin, 2 capsules per serving
FormCapsule
TestingGMP Certified
CoreBiome tributyrin, 2 capsules per servingClinical range: 300-1000mg tributyrin daily
Clinical dose
$1.20/serving$35.95 · 60 Capsules
Ideal for: Patented CoreBiome tributyrin in an allergy-friendly formula
Not ideal for: Budget buyers, or those who want the exact tributyrin mg stated on the label
Pros
- Patented CoreBiome tributyrin (clinically studied)
- Free of gluten and major allergens
- GMP-certified, made in USA
- 1-for-1 Vitamin Angels donation program
Cons
- Most expensive option (~$0.96/serving)
- Two capsules per serving
- Exact tributyrin mg not listed
Pairs Well With
Frequently taken together based on complementary benefits
Berberine
Peak Performance Super Berberine + Wild Bitter Melon
Berberine HCl + bitter melon per serving
Psyllium Husk
NOW Foods Psyllium Husk Powder
7g per serving (1 tablespoon) providing 6g fiber
How to Choose
Choose Tributyrin Over Sodium Butyrate
Tributyrin is a triglyceride that protects butyrate through the stomach, delivering it to the colon where it is needed. Sodium butyrate releases immediately in the stomach, where most butyrate is absorbed before reaching target tissues. Tributyrin also eliminates the notoriously unpleasant rancid odor of free butyrate. CoreBiome is a patented tributyrin ingredient used in several quality products.
Effective Dose Range
Look for 300-1000mg tributyrin per daily serving. Most studies on butyrate gut health benefits used doses equivalent to 300-600mg tributyrin. Higher doses (750-1000mg) may be beneficial for post-antibiotic recovery or more significant gut barrier concerns. Start at the lower end and increase gradually.
Ready to Buy?
BodyBio Butyrate
9/10$1.27/servingBest for: Overall gut health with mineral-buffered butyrate
The best tributyrin supplement delivers 300-1000mg tributyrin per serving in an enteric or lipid-coated capsule for targeted colon delivery, with third-party testing for purity.
Evidence:Review (2011) · moderate confidence[#1]. See full reference list below.Read Our Full Tributyrin Research Guide
Evidence level, dosage, side effects, and more →
Already taking supplements?
Check how Tributyrin fits with your current stack — interactions, timing, and optimization →
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Frequently Asked Questions
What is the best butyrate supplement?
What is the best butyrate supplement?
The best butyrate supplement uses tributyrin rather than sodium butyrate for targeted colonic delivery. BodyBio Butyrate is the most established overall option. Avoid sodium butyrate products, which release butyrate prematurely in the stomach.
Evidence:Review (2011) · moderate confidence[#1]. See full reference list below.Is tributyrin the same as butyrate?
Is tributyrin the same as butyrate?
Tributyrin is a triglyceride (fat) that contains three butyrate molecules bound to a glycerol backbone. When it reaches the intestines, lipase enzymes release the butyrate. This delivery mechanism is what makes tributyrin superior to free butyrate salts — it protects butyrate from premature absorption in the stomach.
What dose of tributyrin is effective for gut support?
What dose of tributyrin is effective for gut support?
Most clinical and observational studies use 300-600mg of tributyrin daily, typically split into two or three doses with meals. Higher doses do not provide additional benefit and may cause mild digestive upset.
When is the best time to take tributyrin?
When is the best time to take tributyrin?
Take tributyrin with meals to improve tolerability and spread butyrate delivery throughout the day. Splitting doses between breakfast and dinner matches the natural fermentation cycle of fiber in the colon.
Continue Reading
Supplement Guide
Berberine
Bottom line: Berberine rivals metformin for blood sugar control in clinical trials. Best for prediabetes and metabolic support at 500mg 2-3x daily — but watch for GI side effects.
Condition GuideGut Health & Digestion
ArticleDo Probiotics Actually Work? A Complete Evidence-Based Guide
References
- ReviewCanani RB, Costanzo MD, Leone L, et al. (2011). Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World Journal of Gastroenterology. DOI PubMed
- ReviewLiu H, Wang J, He T, et al. (2018). Butyrate: A Double-Edged Sword for Health?. Advances in Nutrition. DOI PubMed