General Dosage
40mg UC-II daily, taken on an empty stomach (important for oral tolerance mechanism)
Maximum dose: 40mg daily is the studied dose; higher doses have not shown additional benefit and may impair oral tolerance
UC-II (Undenatured Type II Collagen) Dosage Guide
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Dosage Recommendations
General recommendation: 40mg UC-II daily, taken on an empty stomach (important for oral tolerance mechanism)
Timing: Take on an empty stomach, ideally before bed or first thing in the morning — food may denature the collagen and reduce efficacy
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Knee osteoarthritis | 40mg daily on empty stomach | Moderate |
| Exercise-related joint discomfort | 40mg daily on empty stomach | Moderate |
| General joint support | 40mg daily on empty stomach | Moderate |
Upper limit: 40mg daily is the studied dose; higher doses have not shown additional benefit and may impair oral tolerance
Timing & Absorption
Take on an empty stomach, ideally before bed or first thing in the morning — food may denature the collagen and reduce efficacy
Can be taken with or without food.
References
- Lugo JP, Saiber ZM, Yao X, et al. (2013). Undenatured type II collagen (UC-II) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition. DOI PubMed
- Lugo JP, Saiber ZM, Lai JN, et al. (2016). Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutrition Journal. DOI PubMed
- Crowley DC, Lau FC, Sharma P, et al. (2009). Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International Journal of Medical Sciences. DOI PubMed