Forms Comparison
| Form | Bioavailability | Best For |
|---|---|---|
| UC-II (Patented) | N/A (works via oral tolerance, not systemic absorption) | Joint pain — the only form with clinical trial support; must remain undenatured |
Types of UC-II (Undenatured Type II Collagen): Forms & Bioavailability
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UC-II (Patented)
Bioavailability: N/A (works via oral tolerance, not systemic absorption). Best for: Joint pain — the only form with clinical trial support; must remain undenatured.
References
- Lugo JP, Saiber ZM, Yao X, et al. (2013). Undenatured type II collagen (UC-II) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition. DOI PubMed
- Lugo JP, Saiber ZM, Lai JN, et al. (2016). Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutrition Journal. DOI PubMed
- Crowley DC, Lau FC, Sharma P, et al. (2009). Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International Journal of Medical Sciences. DOI PubMed