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Types of Vitamin K2 (MK-7): Forms & Bioavailability

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
MK-7 (Menaquinone-7)HighDaily supplementation — long half-life (72 hours), consistent blood levels with once-daily dosing; derived from natto fermentation
MK-4 (Menatetrenone)ModerateHigh-dose therapeutic use — short half-life (1-2 hours), requires multiple daily doses; used at 45 mg/day in Japanese osteoporosis treatment
Full-Spectrum K2 (MK-4 + MK-7)HighComprehensive approach — combines short-acting tissue distribution (MK-4) with long-acting systemic effects (MK-7)

MK-7 (Menaquinone-7)

Bioavailability: High. Best for: Daily supplementation — long half-life (72 hours), consistent blood levels with once-daily dosing; derived from natto fermentation.

MK-4 (Menatetrenone)

Bioavailability: Moderate. Best for: High-dose therapeutic use — short half-life (1-2 hours), requires multiple daily doses; used at 45 mg/day in Japanese osteoporosis treatment.

Full-Spectrum K2 (MK-4 + MK-7)

Bioavailability: High. Best for: Comprehensive approach — combines short-acting tissue distribution (MK-4) with long-acting systemic effects (MK-7).

Find the best Vitamin K2 (MK-7) for your needs
Ranked by form, bioavailability, and value
Full Vitamin K2 (MK-7) Guide

References

  1. RCTKnapen MHJ, Drummen NE, Smit E, Vermeer C, Theuwissen E (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International. DOI PubMed
  2. ObservationalGeleijnse JM, Vermeer C, Grobbee DE, et al. (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. Journal of Nutrition. DOI PubMed
  3. RCTSchurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C (2007). Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. DOI PubMed