Integrative Therapeutics Pro-Som - Melatonin-Free Quality Sleep Support for Nighttime Relaxation* - Bedtime Supplement for Restful Sleep Support* - Dairy- & Gluten-Free - 60 Capsules (15 Servings)

Clinical trials typically use L-theanine: 100–400 mg/day; Magnesium: 200–400 mg/day; Magnolia bark: 200–400 mg/day; Theracurmin: studied at 30–90 mg/day (highly bioavailable form). Integrative Therapeutics Pro-Som delivers 4 capsules per serving; 15 servings per 60-capsule bottle, which we classify as Blend relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.

Yes — GMP-manufactured; USA-bottled and tested; branded ingredients (Suntheanine, Theracurmin). Third-party testing verifies ingredient identity and label accuracy.

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Magnolia bark extract has GABA-modulating activity and may potentiate benzodiazepines, barbiturates, and other CNS depressants — avoid combining with prescription sleep aids or anti-anxiety medications without physician guidance. Magnesium at supplemental doses can reduce absorption of certain antibiotics (fluoroquinolones, tetracyclines) and bisphosphonates — separate by 2 hours. Theracurmin (curcumin) has mild CYP3A4 inhibition potential and may affect drugs metabolized by this pathway.

L-theanine, magnesium, and magnolia bark have well-established long-term safety profiles at supplemental doses. High-dose magnesium (above 350 mg supplemental/day) can cause loose stools — ensure your total magnesium intake from all supplements stays within tolerated range. Magnolia bark has traditional use spanning centuries in East Asian medicine with no documented long-term toxicity. Theracurmin at clinical doses is considered safe for long-term use based on curcumin safety data.

Magnesium is the primary ingredient with GI side effect potential — high doses cause osmotic diarrhea in sensitive individuals. The magnesium form matters: magnesium glycinate (typical in sleep formulas) is better tolerated than magnesium oxide. Theracurmin's enhanced bioavailability means its curcumin effects are delivered at lower total doses, reducing GI irritation compared to standard curcumin supplements. L-theanine and magnolia bark are both GI-neutral.

Pro-Som pairs well with a daytime vitamin D supplement (which supports sleep via melatonin synthesis pathways) and an omega-3 fish oil (which has complementary neuroinflammation benefits). Do not combine with melatonin unless specifically advised by a physician — the formula is designed as a melatonin-free alternative. Avoid stacking with other magnolia bark or valerian supplements due to overlapping GABA-modulating effects.

Take 4 capsules approximately 30–60 minutes before bedtime with water. Avoid alcohol on nights when using Pro-Som — magnolia bark's GABA effects combine with alcohol's CNS depression unpredictably. Not recommended for use before driving or operating machinery. Pregnant or breastfeeding women should not use this formula without physician approval due to magnolia bark.

L-theanine and magnolia bark's calming effects are felt acutely within 30–60 minutes of ingestion, making the first-night experience noticeable for many users. Magnesium's muscle relaxation effect is also rapid. The full sleep quality and sleep maintenance benefits (reduced waking after sleep onset) typically manifest after 1–2 weeks of nightly use as the cumulative effect of the formula builds. Theracurmin's neuroinflammation benefits are more gradual, over 4–6 weeks.