Integrative Therapeutics Calcium D-Glucarate - Daily Support for Detoxification Systems*- Supports Healthy Immune Function & Estrogen Metabolism* - Gluten & Dairy-Free - 90 Capsules (30 Servings)
$0.49/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
3 capsules per serving (90 capsules, 30 servings) of Calcium D-Glucarate per capsule from Integrative Therapeutics. Best for adults seeking estrogen metabolism support, hormonal detoxification, and immune function support via…
Why we recommend this
Calcium D-Glucarate is a specialized research-backed compound rarely formulated to clinical standards in the mass market. Integrative Therapeutics clinical-grade manufacturing makes this a trustworthy source for a compound where potency matters significantly for estrogen metabolism and glucuronidation support.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
At 30 servings per bottle and $44.00 per unit this is one of the more expensive ongoing protocols in the IT line. The 3-capsule daily burden and monthly repurchase cadence require committed compliance.
Dose & form
- Serving
- 3 capsules per serving (90 capsules, 30 servings)
- Form
- Capsule
- Clinical range
- Clinical studies use 1500-3000mg calcium D-glucarate per day; 3-capsule serving aligns with standard clinical doses
- Dose adequacy
- Full
- Supply
- 90 servings · $0.49/serving
- UPC
- 871791000643
Who it's best for
Adults seeking estrogen metabolism support, hormonal detoxification, and immune function support via calcium D-glucarate supplementation
Who should skip it
Those wanting a simple calcium supplement - Calcium D-Glucarate is a specialized detox compound, not a calcium source for bone health
Pros
- Calcium D-glucarate specifically targets glucuronidation - key phase II liver detox pathway for estrogen and environmental toxins
- 215 reviews at 4.7 stars for a specialized detox/hormonal compound
- Gluten-free and dairy-free with clean excipient profile
- 45+ year clinical brand with GMP manufacturing ensures authentic compound
Cons
- Only 30 servings per 90-capsule bottle - monthly repurchase at $44.00
- 3-capsule daily dose is a moderate daily pill burden
- Exact mg per capsule not disclosed in listing
What customers say
4.7★ across 215 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Calcium D-Glucarate?
What is the clinical dose for Calcium D-Glucarate?
Clinical trials typically use Clinical studies use 1500-3000mg calcium D-glucarate per day; 3-capsule serving aligns with standard clinical doses. IT Calcium D-Glucarate delivers 3 capsules per serving (90 capsules, 30 servings), which we classify as Full relative to that range.
How does IT Calcium D-Glucarate compare to similar Capsule?
How does IT Calcium D-Glucarate compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is IT Calcium D-Glucarate third-party tested?
Is IT Calcium D-Glucarate third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Calcium D-glucarate may interact with medications that are glucuronidated by the liver, theoretically accelerating clearance of drugs metabolized via this pathway including some hormonal medications, NSAIDs, and antibiotics. Consult your prescriber if on hormonal contraceptives or HRT.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Long-term calcium D-glucarate supplementation is generally well tolerated in clinical studies. The compound is a natural salt found in fruits and vegetables. Prolonged use at clinical doses should be guided by a healthcare provider particularly for those monitoring hormone levels.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Calcium D-glucarate is well tolerated digestively at typical doses. Some users report mild GI discomfort when starting - taking with food resolves this for most. The 4.7-star rating from 215 reviews reflects good tolerability.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Pairs well with DIM and cruciferous vegetable extracts for comprehensive estrogen detox support. Complements antioxidant vitamins and probiotics. Avoid stacking with other glucuronidation-pathway supplements without practitioner guidance.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 3 capsules daily with food. Consistent daily use is important - calcium D-glucarate works by inhibiting beta-glucuronidase enzyme activity which requires sustained blood levels. Healthcare provider should guide protocol duration. Not for use during pregnancy.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Improvements in detox pathway support and estrogen metabolism markers are measurable in blood after 4-8 weeks of consistent use. Subjective improvements in PMS-related symptoms associated with estrogen dominance may emerge within 1-3 menstrual cycles.
