Integrative Therapeutics OsteoPrime Ultra - Supplement for Supporting Healthy Bones* - Supports Bones & Calcium Absorption* - Includes Essential Vitamins & Minerals - 120 Count (30 Servings)

Clinical trials typically use 500-600mg supplemental calcium, 1-2 times daily. IT OsteoPrime Ultra Bone Support delivers 4 tablets daily (120 tablets, 30 servings), which we classify as Blend relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Tablet vs alternatives), dose adequacy, and third-party testing.

Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Calcium supplements can interfere with absorption of thyroid medications, bisphosphonates (alendronate), quinolone antibiotics, and iron — separate these by at least 2 hours. Vitamin D at supplemental doses can increase calcium absorption significantly; those on thiazide diuretics should monitor calcium levels. Zinc at higher doses can compete with copper absorption.

Long-term calcium supplementation without monitoring can contribute to hypercalcemia or kidney stone risk in susceptible individuals. Vitamin D accumulates as a fat-soluble vitamin — long-term high-dose supplementation should be monitored with periodic blood tests. The zinc and niacin in this formula are at supplemental levels unlikely to cause toxicity at the recommended dose.

Calcium can cause constipation in some users, particularly calcium carbonate forms. The formula includes multiple calcium forms which may reduce this effect compared to single-form calcium products. Taking with food as directed helps minimize digestive discomfort. Niacin at low doses (as in a bone formula) rarely causes flushing.

This is a comprehensive bone formula — avoid stacking with separate high-dose calcium, vitamin D, or zinc products to prevent over-supplementation. Works well alongside magnesium if additional magnesium is needed. Check total vitamin D intake across all supplements to stay within safe limits (4000 IU/day upper limit for adults).

Take 4 tablets daily with food — the label recommends not exceeding the suggested dose. Split the daily dose across two meals if the 4-tablet load causes GI discomfort. Do not take within 2 hours of thyroid medications or bisphosphonates. Annual vitamin D and calcium blood monitoring is prudent for long-term users.

Bone mineral density improvements from calcium and vitamin D supplementation are measurable after 6–12 months on DEXA scans in clinical studies. Short-term bone remodeling markers can change within 3 months. This is a long-term support product rather than one with rapid noticeable effects.