Integrative Therapeutics Pure Omega HP - Fish Oil Supplement for Nutritional Support - Supports Heart Health* - No Fishy Burps - Sustainably Sourced - Gluten & Dairy-Free - 120 Softgels (120 Servings)
$0.40/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
375 mg EPA + 125 mg DHA + 75 mg other omega-3s per softgel (575 mg total omega-3 per serving) of EPA (375 mg) + DHA (125 mg) per softgel…
Why we recommend this
For daily maintenance omega-3 supplementation, the Pure Omega HP is a practitioner-trusted, clean-label option with transparent third-party testing and the rosemary preservation system that prevents rancidity without synthetic preservatives. The 120-count bottle keeps monthly cost reasonable at maintenance dosing.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
At 375 mg EPA + 125 mg DHA per softgel, reaching the 1–2 g EPA+DHA clinical target requires 2–4 softgels daily, which increases pill burden and cost. The Pure Omega Ultra HP or Liquid variants offer higher per-serving concentrations for users needing therapeutic doses.
Dose & form
- Serving
- 375 mg EPA + 125 mg DHA + 75 mg other omega-3s per softgel (575 mg total omega-3 per serving)
- Form
- Softgel
- Clinical range
- 1000–4000 mg EPA+DHA daily; this product delivers 500 mg EPA+DHA per softgel — requires 2–8 softgels to reach clinical range
- Dose adequacy
- Partial
- Supply
- 120 servings · $0.40/serving
- UPC
- 871791107595
Who it's best for
Daily omega-3 users wanting a convenient once-daily softgel from sustainably sourced fish with third-party potency testing
Who should skip it
Those requiring high therapeutic EPA doses (>1 g EPA/day) who would need multiple softgels or a higher-concentrate formula
Pros
- Proprietary rosemary preservation system prevents oxidation without synthetic antioxidants
- Third-party tested with results available to consumers — above industry standard transparency
- Molecular distillation removes heavy metals, PCBs, and lipophilic contaminants
- 120-count bottle delivers a full 4-month supply at once-daily dosing
Cons
- Only 500 mg EPA+DHA per softgel — lower concentration than ultra-HP or liquid variants
- Multiple softgels required for clinical-range anti-inflammatory or cardiovascular dosing
- Contains tuna in addition to small pelagic fish — broader allergen profile than some fish oils
What customers say
4.6★ across 233 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for EPA (375 mg) + DHA (125 mg) per softgel?
What is the clinical dose for EPA (375 mg) + DHA (125 mg) per softgel?
Clinical trials typically use 1000–4000 mg EPA+DHA daily; this product delivers 500 mg EPA+DHA per softgel — requires 2–8 softgels to reach clinical range. IT Pure Omega HP Fish Oil Softgels delivers 375 mg EPA + 125 mg DHA + 75 mg other omega-3s per softgel (575 mg total omega-3 per serving), which we classify as Partial relative to that range.
How does IT Pure Omega HP Fish Oil Softgels compare to similar Softgel?
How does IT Pure Omega HP Fish Oil Softgels compare to similar Softgel?
See the "Also consider" section below for two alternatives. Choose based on form preference (Softgel vs alternatives), dose adequacy, and third-party testing.
Is IT Pure Omega HP Fish Oil Softgels third-party tested?
Is IT Pure Omega HP Fish Oil Softgels third-party tested?
Yes — Third-party tested for purity and potency; molecular distillation; results available to consumers. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Omega-3 fatty acids at doses above 1 g EPA+DHA/day may have additive anticoagulant effects with warfarin, aspirin, or clopidogrel. At 500 mg EPA+DHA per softgel, once-daily use is unlikely to reach clinically significant anticoagulant thresholds, but inform your physician if you are on any anticoagulant therapy. Omega-3s may mildly lower blood pressure, which can be additive with antihypertensive medications.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Long-term omega-3 supplementation at 500–2000 mg EPA+DHA daily is safe based on extensive clinical evidence. The molecular distillation process removes heavy metals and PCBs, mitigating bioaccumulation risk from chronic fish-oil use. At once-daily dosing (500 mg EPA+DHA), the product is within the range universally recognised as safe for healthy adults.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
The rosemary preservation system and molecular distillation significantly reduce the fishy burp-back that is the most common side effect of fish oil supplements. Taking with a meal further reduces GI discomfort. At once-daily dosing, GI effects are minimal. Users sensitive to high-dose fish oil may prefer starting at the low end of dosing and adjusting over time.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Compatible with most daily supplement regimens. Fat-soluble vitamins (D3, K2, A, E) may absorb better when taken alongside omega-3 softgels since the lipid matrix aids absorption. Avoid duplicating omega-3 intake from multiple fish oil products simultaneously without tracking total EPA+DHA toward safe upper limits. Compatible with magnesium, multivitamins, and probiotics.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Swallow 1 softgel daily with food, or as recommended by a healthcare professional. Do not chew. Refrigeration is not mandatory but extends freshness if desired. Not suitable for those with fish allergies (contains anchovy, herring, mackerel, sardine, tuna). Consult your physician before use if pregnant, breastfeeding, or on anticoagulant medications.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
At once-daily dosing (500 mg EPA+DHA), steady-state Omega-3 Index improvement takes approximately 8–12 weeks. Cardiovascular and triglyceride benefits at this dose level are modest and cumulative over months. Anti-inflammatory benefits require consistent daily intake over 8–16 weeks. For faster results, practitioners often recommend 2–3 softgels daily to accelerate omega-3 tissue incorporation.
