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7-Keto DHEA Research & Evidence

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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Evidence Level

Preliminary

7-Keto DHEA has a plausible mechanism (thyroid/mitochondrial metabolic boost) and two positive RCTs, but the evidence base is very small, industry-funded, and both studies are from the same research group. No independent replication exists. The non-hormonal profile is a genuine advantage over DHEA. More research is needed before confident recommendations can be made.

Evidence by Condition

ConditionStudied DoseEvidence
Weight management200 mg daily in two divided dosesPreliminary
Full 7-Keto DHEA Guide

References

  1. RCTZenk JL, Frestedt JL, Kuskowski MA (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. Journal of Nutritional Biochemistry. DOI PubMed
  2. ReviewJeyaprakash N, Maeder S, Janka H, Stute P (2023). A systematic review of the impact of 7-keto-DHEA on body weight.. Archives of gynecology and obstetrics. DOI PubMed