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7-Keto DHEA Side Effects & Safety

Evidence:Preliminary
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally well tolerated in short-term trials
  • No sex hormone changes detected
  • Long-term safety data lacking

Drug & Supplement Interactions

  • Thyroid medications — may affect thyroid hormone levels
  • DHEA supplements — unclear interaction with parent hormone
  • Anti-doping — may trigger positive tests in some sports organizations

Maximum Dose

Do not exceed: 200 mg/day is the dose used in trials; higher doses not studied

Full 7-Keto DHEA Guide

References

  1. RCTZenk JL, Frestedt JL, Kuskowski MA (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. Journal of Nutritional Biochemistry. DOI PubMed
  2. ReviewJeyaprakash N, Maeder S, Janka H, Stute P (2023). A systematic review of the impact of 7-keto-DHEA on body weight.. Archives of gynecology and obstetrics. DOI PubMed