General Dosage
1500-3000mg calcium D-glucarate daily in divided doses
Maximum dose: 3000mg daily; higher doses are not well-studied in humans
Calcium D-Glucarate Dosage Guide
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Dosage Recommendations
General recommendation: 1500-3000mg calcium D-glucarate daily in divided doses
Timing: Divided into 2-3 doses throughout the day with meals • Take with food for best absorption.
Dosage by Condition
Estrogen metabolism support
1500-3000mg daily in 2-3 divided dosesPreliminary
General detoxification support
1500mg dailyPreliminary
Combined with DIM protocol
1500-2000mg daily alongside 100-200mg DIMPreliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Estrogen metabolism support | 1500-3000mg daily in 2-3 divided doses | Preliminary |
| General detoxification support | 1500mg daily | Preliminary |
| Combined with DIM protocol | 1500-2000mg daily alongside 100-200mg DIM | Preliminary |
Upper limit: 3000mg daily; higher doses are not well-studied in humans
Timing & Absorption
Divided into 2-3 doses throughout the day with meals
Best taken with food for optimal absorption.
References
- Walaszek Z, Szemraj J, Hanausek M, Adams AK, Sherman U (1996). D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat. Nutrition Research. DOI
- Hanausek M, Walaszek Z, Slaga TJ (2003). Detoxifying cancer causing agents to prevent cancer. Integrative Cancer Therapies. DOI PubMed