Safety Profile
Overall safety rating: Generally Safe
Calcium D-Glucarate Side Effects & Safety
Evidence:Preliminary
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Potential Side Effects
- Mild GI symptoms — bloating, loose stools, or stomach discomfort (uncommon)
- May reduce effectiveness of medications cleared via glucuronidation (see interactions)
- Generally very well-tolerated at standard doses
Drug & Supplement Interactions
- Medications cleared via glucuronidation — by enhancing glucuronidation, calcium D-glucarate may increase the elimination of drugs processed through this pathway (acetaminophen, lorazepam, some statins); consult pharmacist
- Hormonal medications — may enhance estrogen clearance; monitor if on HRT or hormonal contraceptives
- Alcohol — glucuronidation processes alcohol metabolites; theoretical interaction at high doses
Maximum Dose
Do not exceed: 3000mg daily; higher doses are not well-studied in humans