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Calcium D-Glucarate Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Mild GI symptoms — bloating, loose stools, or stomach discomfort (uncommon)
  • May reduce effectiveness of medications cleared via glucuronidation (see interactions)
  • Generally very well-tolerated at standard doses

Drug & Supplement Interactions

  • Medications cleared via glucuronidation — by enhancing glucuronidation, calcium D-glucarate may increase the elimination of drugs processed through this pathway (acetaminophen, lorazepam, some statins); consult pharmacist
  • Hormonal medications — may enhance estrogen clearance; monitor if on HRT or hormonal contraceptives
  • Alcohol — glucuronidation processes alcohol metabolites; theoretical interaction at high doses

Maximum Dose

Do not exceed: 3000mg daily; higher doses are not well-studied in humans

Full Calcium D-Glucarate Guide

References

  1. (). D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat. Nutrition Research. DOI
  2. (). Detoxifying cancer causing agents to prevent cancer. Integrative Cancer Therapies. DOI