Safety Profile
Overall safety rating: Generally Safe
Capsaicin / Cayenne Side Effects & Safety
Evidence:Moderate
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Potential Side Effects
- GI burning, heartburn, and stomach discomfort (capsaicin forms)
- Diarrhea at higher doses
- Sweating and flushing
- Capsinoids avoid most GI side effects
Drug & Supplement Interactions
- Antacids/PPIs — capsaicin may counteract acid-reducing medications
- Blood thinners — capsaicin may have mild antiplatelet effects
- Theophylline — capsaicin may increase absorption
Maximum Dose
Do not exceed: 10 mg capsaicin/day; higher doses cause significant GI discomfort