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DGL Licorice — Frequently Asked Questions

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Frequently Asked Questions

What is the difference between DGL and regular licorice?

Regular licorice contains glycyrrhizin, which inhibits cortisol metabolism and causes pseudo-aldosteronism (hypertension, fluid retention, low potassium). DGL has glycyrrhizin removed, eliminating these risks while retaining the gastroprotective compounds. Always use DGL for medicinal purposes, especially long-term.

Why do DGL tablets need to be chewed?

Traditional teaching holds that chewing DGL tablets mixes them with saliva, which contains epidermal growth factor (EGF) that synergizes with DGL for mucosal repair. While this mechanism is debated, clinical studies typically used chewable forms. Swallowing DGL capsules may still provide benefit but chewable is the traditional recommendation.

Can I take DGL with a PPI?

Yes. DGL works by a completely different mechanism than PPIs. PPIs reduce acid production; DGL enhances mucosal defense. They are complementary, not conflicting. DGL may provide additional symptom relief and mucosal support while taking a PPI, and may support PPI tapering when appropriate under medical guidance.

Full DGL Licorice Guide

References

  1. (). Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut. DOI
  2. (). An extract of Glycyrrhiza glabra (GutGard) alleviates symptoms of functional dyspepsia: a randomized, double-blind, placebo-controlled study. Evidence-Based Complementary and Alternative Medicine. DOI