General Dosage
250-1000 mg daily of liposomal or S-acetyl glutathione
Maximum dose: 1500 mg/day used in clinical studies without significant adverse effects
L-Glutathione Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 250-1000 mg daily of liposomal or S-acetyl glutathione
Timing: On an empty stomach for best absorption; morning or split AM/PM
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General antioxidant support | 250-500 mg daily (liposomal) | Moderate |
| Liver and detox support | 500-1000 mg daily | Moderate |
| Skin brightening | 500 mg daily for 4+ weeks | Moderate |
| Immune support | 500-1000 mg daily | Moderate |
Upper limit: 1500 mg/day used in clinical studies without significant adverse effects
Timing & Absorption
On an empty stomach for best absorption; morning or split AM/PM
Can be taken with or without food.
References
- Richie JP, Nichenametla S, Neidig W, et al. (2015). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition. DOI PubMed
- Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. (2017). Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology. DOI PubMed
- Forman HJ, Zhang H, Rinna A. (2009). Glutathione: overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine. DOI PubMed