Safety Profile
Overall safety rating: Generally Safe
L-Glutathione Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Generally very well tolerated
- Mild bloating or GI discomfort in some individuals
- Rare allergic reactions
- Long-term safety of very high oral doses is not fully established
Drug & Supplement Interactions
- Chemotherapy drugs — glutathione may reduce efficacy of certain chemotherapeutics; consult oncologist
- Nitroglycerin — glutathione may enhance hypotensive effects
- Immunosuppressants — glutathione may enhance immune function, potentially counteracting immunosuppression
Maximum Dose
Do not exceed: 1500 mg/day used in clinical studies without significant adverse effects
References
- Richie JP, Nichenametla S, Neidig W, et al. (2015). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition. DOI PubMed
- Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. (2017). Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology. DOI PubMed
- Forman HJ, Zhang H, Rinna A. (2009). Glutathione: overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine. DOI PubMed