Safety Profile
Overall safety rating: Safe with Caution
Manganese Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Generally well-tolerated at dietary levels
- Headache and insomnia at higher supplemental doses
- Neurotoxicity with chronic high-dose exposure (>11mg/day) — manganism resembles Parkinson's disease
- People with liver disease are at increased risk of manganese toxicity due to impaired biliary excretion
Drug & Supplement Interactions
- Iron supplements compete for the same absorption transporter (DMT-1)
- Calcium and phosphorus may reduce manganese absorption
- Antacids and PPIs may alter manganese absorption
- Quinolone and tetracycline antibiotics — manganese can reduce their absorption
Maximum Dose
Do not exceed: 11mg/day (NIH UL); excess manganese is neurotoxic
References
- Strause L, Saltman P, Smith KT, Bracker M, Andon MB (1994). Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. Journal of Nutrition. DOI PubMed
- Aschner JL, Aschner M (2005). Nutritional aspects of manganese homeostasis. Molecular Aspects of Medicine. DOI PubMed
- O'Neal SL, Zheng W (2015). Manganese toxicity upon overexposure: a decade in review. Current Environmental Health Reports. DOI PubMed