General Dosage
100-200mcg vitamin K2 (MK-7) daily; nattokinase 2000 FU daily if desired
Maximum dose: 360mcg MK-7/day; 4000 FU nattokinase/day
Natto / Vitamin K2 (for Arteries) Dosage Guide
Evidence:Moderate
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Dosage Recommendations
General recommendation: 100-200mcg vitamin K2 (MK-7) daily; nattokinase 2000 FU daily if desired
Timing: Take K2 with a fat-containing meal; nattokinase can be taken on an empty stomach • Take with food for best absorption.
Dosage by Condition
Arterial calcification prevention
180-200mcg MK-7 dailyModerate
Arterial stiffness
180mcg MK-7 daily for 3+ yearsModerate
Blood flow support
2000-4000 FU nattokinase dailyModerate
General cardiovascular maintenance
100mcg MK-7 dailyModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Arterial calcification prevention | 180-200mcg MK-7 daily | Moderate |
| Arterial stiffness | 180mcg MK-7 daily for 3+ years | Moderate |
| Blood flow support | 2000-4000 FU nattokinase daily | Moderate |
| General cardiovascular maintenance | 100mcg MK-7 daily | Moderate |
Upper limit: 360mcg MK-7/day; 4000 FU nattokinase/day
Timing & Absorption
Take K2 with a fat-containing meal; nattokinase can be taken on an empty stomach
Best taken with food for optimal absorption.
References
- RCTKnapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C (2015). Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thrombosis and Haemostasis. DOI PubMed
- ObservationalGeleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. Journal of Nutrition. DOI PubMed
- RCTKurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T (2015). A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Scientific Reports. DOI PubMed