General Dosage
250-500mg daily, taken in the morning
Maximum dose: 1200mg/day (doses above this have not been studied for safety in humans)
NMN Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 250-500mg daily, taken in the morning
Timing: Morning on an empty stomach; sublingual forms taken under the tongue for 60-90 seconds before swallowing
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General longevity / NAD+ support | 250-500mg daily | Emerging |
| Insulin sensitivity | 250mg daily | Moderate |
| Exercise performance | 600-1200mg daily | Emerging |
Upper limit: 1200mg/day (doses above this have not been studied for safety in humans)
Timing & Absorption
Morning on an empty stomach; sublingual forms taken under the tongue for 60-90 seconds before swallowing
Can be taken with or without food.
References
- Yi L, Maier AB, Tao R, et al. (2022). The efficacy and safety of beta-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. DOI PubMed
- Yoshino M, Yoshino J, Kayser BD, et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. DOI PubMed
- Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M (2022). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition. DOI PubMed