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NMN Dosage Guide

Evidence:Emerging
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

250-500mg daily, taken in the morning

Maximum dose: 1200mg/day (doses above this have not been studied for safety in humans)

Dosage Recommendations

General recommendation: 250-500mg daily, taken in the morning

Timing: Morning on an empty stomach; sublingual forms taken under the tongue for 60-90 seconds before swallowing

Dosage by Condition

General longevity / NAD+ support
250-500mg dailyEmerging
Insulin sensitivity
250mg dailyModerate
Exercise performance
600-1200mg dailyEmerging

Upper limit: 1200mg/day (doses above this have not been studied for safety in humans)

Timing & Absorption

Morning on an empty stomach; sublingual forms taken under the tongue for 60-90 seconds before swallowing

Can be taken with or without food.

Find a NMN with the right dose
We verify actual dosage against clinical research
Full NMN Guide

References

  1. RCTYoshino M, Yoshino J, Kayser BD, et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. DOI PubMed
  2. RCTLiao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M (2022). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition. DOI PubMed
  3. Noh H, Sen Gupta S, Seshadri S, Viñals Gonzalez X (2026). NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis.. Journal of assisted reproduction and genetics. DOI PubMed
  4. Yang DL, Chao KC, Yang HT, Chen KH, et al. (2026). Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise.. Journal of the International Society of Sports Nutrition. DOI PubMed
  5. Zhou L, Lan X, Wang M, Li X, et al. (2026). Restoring NAD⁺-Sirtuins Signaling: A Novel Approach to Combat Male Reproductive Aging.. The world journal of men's health. DOI PubMed
  6. RCTChristen S, Redeuil K, Goulet L, Giner MP, et al. (2026). The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.. Nature metabolism. DOI PubMed
  7. Kuerec AH, Wang W, Fokke KDM, Yi L, et al. (2025). Association between blood nicotinamide adenine dinucleotide levels and blood laboratory parameters at baseline and after nicotinamide mononucleotide supplementation in middle-aged healthy individuals: post hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial.. GeroScience. DOI PubMed
Show 4 more references
  1. Meta-analysisWang JP, Wang L, Wang T, Zhang YD, et al. (2025). Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials.. Current pharmaceutical biotechnology. DOI PubMed
  2. Meta-analysisZhang J, Poon ET, Wong SH (2025). Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials.. Critical reviews in food science and nutrition. DOI PubMed
  3. Prokopidis K, Moriarty F, Bahat G, McLean J, et al. (2025). The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.. Journal of cachexia, sarcopenia and muscle. DOI PubMed
  4. Damgaard MV, Treebak JT (2025). NAD+ supplementation for anti-aging and wellness: A PRISMA-guided systematic review.. Aging cell. DOI PubMed