Safety Profile
Overall safety rating: Generally Safe
NMN Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Generally well-tolerated in human trials at doses up to 1200mg/day
- Mild GI discomfort (nausea, bloating) reported by a small number of participants
- Flushing at higher doses due to downstream niacin pathway activity
- Long-term safety data beyond 12 weeks is limited in humans
Drug & Supplement Interactions
- No significant drug interactions identified in clinical trials to date
- Theoretical concern with chemotherapy agents — NAD+ supports DNA repair in all cells, including potentially cancerous ones; consult oncologist before use
- May interact with NAD+-depleting medications; discuss with your healthcare provider
Maximum Dose
Do not exceed: 1200mg/day (doses above this have not been studied for safety in humans)
References
- Yi L, Maier AB, Tao R, et al. (2022). The efficacy and safety of beta-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. DOI PubMed
- Yoshino M, Yoshino J, Kayser BD, et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. DOI PubMed
- Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M (2022). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition. DOI PubMed