General Dosage
600-1,200mg micronized PEA daily, in 2 divided doses
Maximum dose: Up to 1,200mg/day has been used in clinical trials; no dose-limiting toxicity has been identified
Palmitoylethanolamide (PEA) Dosage Guide
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Dosage Recommendations
General recommendation: 600-1,200mg micronized PEA daily, in 2 divided doses
Timing: Take with meals to enhance absorption of this lipophilic compound; split into 2 daily doses • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Chronic pain | 600mg twice daily (1,200mg/day) | Moderate |
| Neuropathic pain | 600mg twice daily for 3 weeks, then 600mg once daily | Moderate |
| General anti-inflammatory | 300-600mg daily | Emerging |
Upper limit: Up to 1,200mg/day has been used in clinical trials; no dose-limiting toxicity has been identified
Timing & Absorption
Take with meals to enhance absorption of this lipophilic compound; split into 2 daily doses
Best taken with food for optimal absorption.
References
- Paladini A, Fusco M, Cenacchi T, et al. (2016). Palmitoylethanolamide, a special food for medical purposes, in the treatment of chronic pain: a pooled data meta-analysis. Pain Physician. PubMed
- Hesselink JM, Hekker TA (2012). Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series. Journal of Pain Research. DOI PubMed
- Petrosino S, Di Marzo V (2017). The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations. British Journal of Pharmacology. DOI PubMed