General Dosage
100-200mg once daily in the morning or early afternoon
Maximum dose: 300mg/day (higher doses have not been adequately studied)
Paraxanthine Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 100-200mg once daily in the morning or early afternoon
Timing: Morning or early afternoon; avoid evening use as it still promotes wakefulness
Dosage by Condition
Focus and alertness
100-200mg once dailyEmerging
Pre-workout energy
200mg taken 30-45 minutes before exerciseEmerging
Caffeine replacement
100mg paraxanthine replaces ~200mg caffeineEmerging
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Focus and alertness | 100-200mg once daily | Emerging |
| Pre-workout energy | 200mg taken 30-45 minutes before exercise | Emerging |
| Caffeine replacement | 100mg paraxanthine replaces ~200mg caffeine | Emerging |
Upper limit: 300mg/day (higher doses have not been adequately studied)
Timing & Absorption
Morning or early afternoon; avoid evening use as it still promotes wakefulness
Can be taken with or without food.
References
- Yoo C, Xing D, Gonzalez D, et al. (2023). Acute paraxanthine ingestion improves cognition and short-term memory and helps sustain attention in a double-blind, placebo-controlled, crossover trial. Nutrients. DOI PubMed
- Xing D, Yoo C, Gonzalez D, et al. (2021). Dose-response of paraxanthine on cognitive function: a double-blind, placebo-controlled, crossover trial. Nutrients. DOI PubMed
- Arnaud MJ (2011). Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handbook of Experimental Pharmacology. DOI PubMed