General Dosage
1-20 billion CFU daily, strain-dependent
Maximum dose: 100 billion CFU/day has been used safely in clinical trials
Probiotics (Lactobacillus) Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 1-20 billion CFU daily, strain-dependent
Timing: Take with or shortly before meals for best survival through stomach acid • Take with food for best absorption.
Dosage by Condition
Antibiotic-associated diarrhea prevention
10-20 billion CFU L. rhamnosus GG dailyStrong
IBS symptoms
10 billion CFU L. plantarum 299v dailyStrong
Infantile colic
100 million CFU L. reuteri DSM 17938 dailyStrong
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Antibiotic-associated diarrhea prevention | 10-20 billion CFU L. rhamnosus GG daily | Strong |
| IBS symptoms | 10 billion CFU L. plantarum 299v daily | Strong |
| Infantile colic | 100 million CFU L. reuteri DSM 17938 daily | Strong |
Upper limit: 100 billion CFU/day has been used safely in clinical trials
Timing & Absorption
Take with or shortly before meals for best survival through stomach acid
Best taken with food for optimal absorption.
References
- Goldenberg JZ, Yap C, Lytvyn L, et al. (2017). Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database of Systematic Reviews. DOI PubMed
- Ducrotté P, Sawant P, Jayanthi V. (2012). Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World Journal of Gastroenterology. DOI PubMed