General Dosage
20mg (1/4 teaspoon) applied to inner arms, chest, or inner thighs once or twice daily
Maximum dose: 40mg daily (OTC); higher doses require prescription
Progesterone Cream (OTC) Dosage Guide
Evidence:Emerging
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Dosage Recommendations
General recommendation: 20mg (1/4 teaspoon) applied to inner arms, chest, or inner thighs once or twice daily
Timing: Evening application may support sleep due to calming metabolites
Dosage by Condition
Perimenopausal symptoms
20mg once or twice daily, cycle days 12-26Emerging
Estrogen dominance
20mg daily during luteal phaseEmerging
Postmenopausal support
20mg daily, 25 days on / 5 days offPreliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Perimenopausal symptoms | 20mg once or twice daily, cycle days 12-26 | Emerging |
| Estrogen dominance | 20mg daily during luteal phase | Emerging |
| Postmenopausal support | 20mg daily, 25 days on / 5 days off | Preliminary |
Upper limit: 40mg daily (OTC); higher doses require prescription
Timing & Absorption
Evening application may support sleep due to calming metabolites
Can be taken with or without food.
References
- RCTLeonetti HB, Longo S, Anasti JN (1999). Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstetrics & Gynecology. DOI PubMed
- RCTWren BG, McFarland K, Edwards L, O'Shea P, Sufi S, Gross B, Eden JA (2000). Effect of sequential transdermal progesterone cream on endometrium, bleeding pattern, and plasma progesterone and salivary progesterone levels in postmenopausal women. Climacteric. DOI PubMed