General Dosage
1-6mg once weekly (off-label longevity dose; prescription required)
Maximum dose: 6mg/week for longevity protocols (daily dosing at transplant doses causes immunosuppression)
Rapamycin (Longevity Context) Dosage Guide
Evidence:Emerging
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Dosage Recommendations
General recommendation: 1-6mg once weekly (off-label longevity dose; prescription required)
Timing: Once weekly dosing (not daily) is used in longevity protocols to allow mTOR reactivation between doses, minimizing immunosuppressive effects
Dosage by Condition
Longevity / anti-aging (off-label)
3-6mg once weeklyEmerging
Immune rejuvenation
0.5-1mg once weeklyEmerging
Organ transplant (approved use)
2-5mg daily (continuous)Strong
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Longevity / anti-aging (off-label) | 3-6mg once weekly | Emerging |
| Immune rejuvenation | 0.5-1mg once weekly | Emerging |
| Organ transplant (approved use) | 2-5mg daily (continuous) | Strong |
Upper limit: 6mg/week for longevity protocols (daily dosing at transplant doses causes immunosuppression)
Timing & Absorption
Once weekly dosing (not daily) is used in longevity protocols to allow mTOR reactivation between doses, minimizing immunosuppressive effects
Can be taken with or without food.
References
- RCTMannick JB, Del Giudice G, Sabatini M, et al. (2014). mTOR inhibition improves immune function in the elderly. Science Translational Medicine. DOI PubMed
- ReviewBlagosklonny MV (2019). Rapamycin for longevity: opinion article. Aging. DOI PubMed
- RCTHarrison DE, Strong R, Sharp ZD, et al. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. DOI PubMed