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Saccharomyces Boulardii Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

250-500mg (5-10 billion CFU) twice daily

Maximum dose: 1,000mg (20 billion CFU) per day

Dosage Recommendations

General recommendation: 250-500mg (5-10 billion CFU) twice daily

Timing: Can be taken at any time relative to antibiotics (antibiotic-resistant)

Dosage by Condition

AAD prevention
250mg twice daily throughout antibiotic courseStrong
C. difficile recurrence prevention
500mg twice daily for 4 weeksStrong
Acute diarrhea (pediatric)
250mg twice daily for 5-7 daysStrong

Upper limit: 1,000mg (20 billion CFU) per day

Timing & Absorption

Can be taken at any time relative to antibiotics (antibiotic-resistant)

Can be taken with or without food.

Full Saccharomyces Boulardii Guide

References

  1. Meta-analysisSzajewska H, Kolodziej M. (2015). Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Alimentary Pharmacology & Therapeutics. DOI PubMed
  2. Meta-analysisMcFarland LV. (2010). Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World Journal of Gastroenterology. DOI PubMed
  3. Li M, Xie Y (2025). Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.. Frontiers in cellular and infection microbiology. DOI PubMed
  4. McFarland LV, Li T (2025). Efficacy and safety of Saccharomyces boulardii CNCM I-745 for the treatment of pediatric acute diarrhea in China: a systematic review and meta-analysis.. Frontiers in cellular and infection microbiology. DOI PubMed
  5. Ma F, Huang H, Tian K, Wang W (2025). Efficacy and Safety of <em>Saccharomyces Boulardii</em> with Standard Quadruple Therapy for Eradication of <em>Helicobacter Pylori </em>in Adults: Meta-Analysis.. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. DOI PubMed
  6. Jiang YZ, Ma K, Cui C, Li ZY, et al. (2025). Effect of Saccharomyces boulardii supplementation to bismuth quadruple therapy on Helicobacter pylori eradication.. BMC gastroenterology. DOI PubMed
  7. Meta-analysisLiu LH, Han B, Tao J, Zhang K, et al. (2023). The effect of Saccharomyces boulardii supplementation on Helicobacter pylori eradication in children: a systematic review and meta-analysis of Randomized controlled trials.. BMC infectious diseases. DOI PubMed
Show 4 more references
  1. Meta-analysisFu H, Li J, Xu X, Xia C, et al. (2022). Effectiveness and Safety of Saccharomyces Boulardii for the Treatment of Acute Gastroenteritis in the Pediatric Population: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Computational and mathematical methods in medicine. DOI PubMed
  2. Meta-analysisSzajewska H, Kołodziej M, Zalewski BM (2020). Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update.. Alimentary pharmacology & therapeutics. DOI PubMed
  3. Zhou BG, Chen LX, Li B, Wan LY, et al. (2019). Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis.. Helicobacter. DOI PubMed
  4. Stier H, Bischoff SC (2017). [Saccharomyces boulardii CNCM I-745 influences the gut-associated immune system].. MMW Fortschritte der Medizin. DOI PubMed