General Dosage
250-500mg (5-10 billion CFU) twice daily
Maximum dose: 1,000mg (20 billion CFU) per day
Saccharomyces Boulardii Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 250-500mg (5-10 billion CFU) twice daily
Timing: Can be taken at any time relative to antibiotics (antibiotic-resistant)
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| AAD prevention | 250mg twice daily throughout antibiotic course | Strong |
| C. difficile recurrence prevention | 500mg twice daily for 4 weeks | Strong |
| Acute diarrhea (pediatric) | 250mg twice daily for 5-7 days | Strong |
Upper limit: 1,000mg (20 billion CFU) per day
Timing & Absorption
Can be taken at any time relative to antibiotics (antibiotic-resistant)
Can be taken with or without food.
References
- Szajewska H, Kolodziej M. (2015). Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Alimentary Pharmacology & Therapeutics. DOI PubMed
- McFarland LV. (2010). Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World Journal of Gastroenterology. DOI PubMed