General Dosage
1.1 mg (women) to 1.3 mg (men) daily as RDA; 400 mg daily for migraine prevention
Maximum dose: No established upper limit — low toxicity due to limited absorption at high doses; excess excreted in urine (causing bright yellow color)
Vitamin B2 (Riboflavin) Dosage Guide
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Dosage Recommendations
General recommendation: 1.1 mg (women) to 1.3 mg (men) daily as RDA; 400 mg daily for migraine prevention
Timing: With meals; split doses for amounts above 50 mg to improve absorption • Take with food for best absorption.
Dosage by Condition
General health
1.1-1.3 mg dailyStrong
Migraine prevention
400 mg daily for at least 3 monthsStrong
Antioxidant support
10-25 mg dailyModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General health | 1.1-1.3 mg daily | Strong |
| Migraine prevention | 400 mg daily for at least 3 months | Strong |
| Antioxidant support | 10-25 mg daily | Moderate |
Upper limit: No established upper limit — low toxicity due to limited absorption at high doses; excess excreted in urine (causing bright yellow color)
Timing & Absorption
With meals; split doses for amounts above 50 mg to improve absorption
Best taken with food for optimal absorption.
References
- Schoenen J, Jacquy J, Lenaerts M (1998). Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial. Neurology. DOI PubMed
- Thompson DF, Saluja HS (2017). Prophylaxis of migraine headaches with riboflavin: a systematic review. Journal of Clinical Pharmacy and Therapeutics. DOI PubMed
- Powers HJ (2003). Riboflavin (vitamin B-2) and health. American Journal of Clinical Nutrition. DOI PubMed