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Vitamin B6 (Pyridoxine) Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

1.3 mg daily (adults 19-50); 1.5 mg (women 51+); 1.7 mg (men 51+)

Maximum dose: 100 mg/day (NIH UL); chronic doses above 200 mg/day risk peripheral neuropathy

Dosage Recommendations

General recommendation: 1.3 mg daily (adults 19-50); 1.5 mg (women 51+); 1.7 mg (men 51+)

Timing: With food to reduce nausea; morning for energy support • Take with food for best absorption.

Dosage by Condition

General health
1.3-2.0 mg dailyStrong
Morning sickness
10-25 mg three times dailyStrong
PMS relief
50-100 mg dailyModerate
Homocysteine reduction
25-50 mg daily with B12 and folateStrong

Upper limit: 100 mg/day (NIH UL); chronic doses above 200 mg/day risk peripheral neuropathy

Timing & Absorption

With food to reduce nausea; morning for energy support

Best taken with food for optimal absorption.

Full Vitamin B6 (Pyridoxine) Guide

References

  1. Meta-analysisWyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM (1999). Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ. DOI PubMed
  2. ReviewACOG Practice Bulletin No. 189 (2018). Nausea and Vomiting of Pregnancy. Obstetrics & Gynecology. DOI PubMed
  3. RCTAdventure-Heart DJ, Madden NA, Delfabbro P (2018). Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.. Perceptual and motor skills. DOI PubMed
  4. Himmerich H, Erbguth F (2014). [Nutrition and dietary supplements in psychiatric diseases].. Der Nervenarzt. DOI PubMed
  5. Lippi G, Plebani M (2012). Hyperhomocysteinemia in health and disease: where we are now, and where do we go from here ?. Clinical chemistry and laboratory medicine. DOI PubMed
  6. Kałużna-Czaplińska J, Socha E, Rynkowski J (2011). B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children.. Nutrition research (New York, N.Y.). DOI PubMed
  7. Meta-analysisMalouf R, Grimley Evans J (2003). The effect of vitamin B6 on cognition.. The Cochrane database of systematic reviews. DOI PubMed
Show 4 more references
  1. Brouwer DA, Welten HT, van Doormaal JJ, Reijngoud DJ, et al. (1998). [Recommended dietary allowance of folic acid is insufficient for optimal homocysteine levels].. Nederlands tijdschrift voor geneeskunde. PubMed
  2. RCTAybak M, Sermet A, Ayyildiz MO, Karakilçik AZ (1995). Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension.. Arzneimittel-Forschung. PubMed
  3. Sermet A, Aybak M, Ulak G, Güzel C, et al. (1995). Effect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists.. Arzneimittel-Forschung. PubMed
  4. Hayasaka S, Saito T, Nakajima H, Takahashi O, et al. (1985). Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina.. The British journal of ophthalmology. DOI PubMed