General Dosage
1.3 mg daily (adults 19-50); 1.5 mg (women 51+); 1.7 mg (men 51+)
Maximum dose: 100 mg/day (NIH UL); chronic doses above 200 mg/day risk peripheral neuropathy
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1.3 mg daily (adults 19-50); 1.5 mg (women 51+); 1.7 mg (men 51+)
Maximum dose: 100 mg/day (NIH UL); chronic doses above 200 mg/day risk peripheral neuropathy
General recommendation: 1.3 mg daily (adults 19-50); 1.5 mg (women 51+); 1.7 mg (men 51+)
Timing: With food to reduce nausea; morning for energy support • Take with food for best absorption.
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General health | 1.3-2.0 mg daily | Strong |
| Morning sickness | 10-25 mg three times daily | Strong |
| PMS relief | 50-100 mg daily | Moderate |
| Homocysteine reduction | 25-50 mg daily with B12 and folate | Strong |
Upper limit: 100 mg/day (NIH UL); chronic doses above 200 mg/day risk peripheral neuropathy
With food to reduce nausea; morning for energy support
Best taken with food for optimal absorption.