General Dosage
20-40mg standardized fruit extract daily (equivalent to Ze 440 or BNO 1095 extracts)
Maximum dose: 40mg standardized extract daily; higher doses have not shown additional benefit and may cause side effects
Vitex (Chasteberry) Dosage Guide
Evidence:Strong
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Dosage Recommendations
General recommendation: 20-40mg standardized fruit extract daily (equivalent to Ze 440 or BNO 1095 extracts)
Timing: Morning on an empty stomach; consistent daily dosing is more important than timing
Dosage by Condition
PMS symptom relief
20mg standardized extract daily for 3+ cyclesStrong
Menstrual cycle regulation
20-40mg standardized extract dailyModerate
Mild hyperprolactinemia
20-40mg daily under medical supervisionModerate
Luteal phase support
20-40mg daily for 3-6 monthsEmerging
| Condition | Recommended Dose | Evidence |
|---|---|---|
| PMS symptom relief | 20mg standardized extract daily for 3+ cycles | Strong |
| Menstrual cycle regulation | 20-40mg standardized extract daily | Moderate |
| Mild hyperprolactinemia | 20-40mg daily under medical supervision | Moderate |
| Luteal phase support | 20-40mg daily for 3-6 months | Emerging |
Upper limit: 40mg standardized extract daily; higher doses have not shown additional benefit and may cause side effects
Timing & Absorption
Morning on an empty stomach; consistent daily dosing is more important than timing
Can be taken with or without food.
References
- RCTSchellenberg R (2001). Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ. DOI PubMed
- Meta-analysisVerkaik S, Moll AC, Steegers-Theunissen RP, et al. (2017). The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. DOI PubMed
- RCTWuttke W, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D (2003). Chaste tree (Vitex agnus-castus) — pharmacology and clinical indications. Phytomedicine. DOI PubMed