Nutricost TUDCA 250mg: Is Nutricost TUDCA 250mg safe to take daily?

Yes, TUDCA at 250mg daily is a standard maintenance dose that is generally well tolerated. Nutricost products are third-party tested for quality and purity. TUDCA is a naturally occurring bile acid in the human body.

Nutricost TUDCA 250mg: Can Nutricost TUDCA cause diarrhea?

TUDCA is a bile acid, and bile acids can stimulate bowel movements. Some users may experience loose stools, especially when starting. Starting with one capsule daily and taking it with food can minimize this effect.

Nutricost TUDCA 250mg: Is Nutricost TUDCA safe to take with liver medications?

TUDCA may interact with other bile acid medications like ursodeoxycholic acid (UDCA) or cholesterol-lowering drugs. Consult your healthcare provider before combining TUDCA with any liver or gallbladder medications.

Nutricost TUDCA 250mg: Can Nutricost TUDCA affect gallbladder function?

TUDCA promotes healthy bile flow, which generally supports gallbladder function. However, if you have gallstones or gallbladder disease, consult your healthcare provider before taking TUDCA, as increased bile flow could theoretically dislodge small stones.

Nutricost TUDCA 250mg: Is Nutricost TUDCA safe during pregnancy?

TUDCA has not been adequately studied in pregnant or breastfeeding women. While it is a naturally occurring bile acid, supplemental doses should be avoided during pregnancy unless specifically recommended by a healthcare provider.

Nutricost TUDCA 250mg: How many Nutricost TUDCA capsules should I take per day?

For general liver maintenance, 1 capsule (250mg) daily is the standard dose. For targeted liver and bile flow support, 2 capsules (500mg) daily can be taken. Start with 1 capsule and increase if needed.

Nutricost TUDCA 250mg: Should I take Nutricost TUDCA with food?

Taking TUDCA with meals is recommended for better tolerance and to align with the body's natural bile acid cycle. TUDCA naturally plays a role in digestion, so taking it with meals is physiologically appropriate.

Nutricost TUDCA 250mg: What is the best time of day to take Nutricost TUDCA?

Taking TUDCA with breakfast or lunch aligns with the body's natural bile acid production cycle. If taking 2 capsules daily, dividing between morning and evening meals provides more consistent levels.

Nutricost TUDCA 250mg: Can I take more than 500mg of Nutricost TUDCA daily?

Clinical research has used TUDCA at doses up to 1500mg daily, but higher doses should be taken under medical supervision. For most users, 250-500mg daily provides adequate liver and bile flow support without the need for higher amounts.

Nutricost TUDCA 250mg: How long does it take for Nutricost TUDCA to work?

Users may notice improvements in digestion and bile flow within 1-2 weeks. Measurable improvements in liver enzyme levels typically require 4-8 weeks of consistent use. Full benefits for liver protection develop with ongoing supplementation.

Nutricost TUDCA 250mg: What is TUDCA?

TUDCA (tauroursodeoxycholic acid) is a water-soluble bile acid formed when taurine conjugates with ursodeoxycholic acid. It occurs naturally in the body in small amounts and has been shown to support liver cell health, bile flow, and reduce cellular stress.

Nutricost TUDCA 250mg: How is TUDCA different from UDCA?

TUDCA is the taurine-conjugated form of UDCA (ursodeoxycholic acid). TUDCA is more water-soluble and may have additional benefits beyond UDCA, including stronger anti-apoptotic and cellular protective effects. UDCA is the prescription form used in many countries.

Nutricost TUDCA 250mg: Does Nutricost TUDCA contain any fillers?

The formula contains TUDCA as the active ingredient with standard capsule excipients. Nutricost uses a clean formulation approach with minimal inactive ingredients needed for proper capsule manufacturing.

Nutricost TUDCA 250mg: What type of capsule does Nutricost TUDCA use?

Nutricost uses standard capsules for their TUDCA product. The capsule shell keeps the bile acid protected from premature degradation and ensures accurate dosing.

Nutricost TUDCA 250mg: Is the TUDCA in Nutricost synthetic or natural?

Supplemental TUDCA is synthesized by conjugating taurine with ursodeoxycholic acid in a controlled manufacturing process. This produces the same molecule found naturally in the body, ensuring identical biological activity.

Nutricost TUDCA 250mg: How effective is Nutricost TUDCA for liver protection?

TUDCA has strong evidence for protecting liver cells from various forms of stress. At 250mg daily, it provides meaningful support for liver health and bile flow. Research shows it can reduce liver cell death markers and improve bile duct function.

Nutricost TUDCA 250mg: Can Nutricost TUDCA help with bile flow issues?

Yes, TUDCA is one of the most effective supplements for supporting healthy bile flow. It helps optimize bile composition and promotes proper bile duct function, which supports fat digestion and liver detoxification.

Nutricost TUDCA 250mg: Is Nutricost TUDCA effective for steroid-related liver support?

TUDCA is popular among athletes for liver support during cycles involving hepatotoxic compounds. While research supports its liver-protective effects, this use should be discussed with a healthcare provider.

Nutricost TUDCA 250mg: Does Nutricost TUDCA help with endoplasmic reticulum stress?

Yes, one of TUDCA's most studied mechanisms is its ability to act as a chemical chaperone that reduces endoplasmic reticulum (ER) stress. This cellular protective effect is distinct from other liver supplements and has implications for metabolic health.

Nutricost TUDCA 250mg: How many capsules come in a bottle of Nutricost TUDCA?

Each bottle contains 60 capsules. At 1 capsule daily (250mg), this provides a 2-month supply. At 2 capsules daily (500mg), the bottle lasts 1 month.

Nutricost TUDCA 250mg: What are the dimensions of the Nutricost TUDCA bottle?

The bottle measures approximately 2.13 x 2.13 x 3.9 inches — a compact size that fits easily in a medicine cabinet or supplement organizer.

Nutricost TUDCA 250mg: How should I store Nutricost TUDCA?

Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle sealed when not in use. No refrigeration is required, but avoid storing in humid environments.

Nutricost TUDCA 250mg: Is Nutricost TUDCA suitable for vegans?

TUDCA itself is a synthetic bile acid and does not contain animal products. However, check the specific capsule type on the label — some capsules use gelatin while others use plant-based materials.

Nutricost TUDCA 250mg: Is Nutricost TUDCA gluten-free?

Yes, Nutricost TUDCA is labeled gluten-free. It is also non-GMO verified, making it suitable for people with gluten sensitivities or celiac disease.

Nutricost TUDCA 250mg: Does Nutricost TUDCA contain any common allergens?

The product is free from gluten and is non-GMO. Nutricost provides clear allergen labeling on their products. Check the label for the most current allergen information regarding dairy, soy, and other common allergens.

Double Wood Supplements TUDCA 500mg: Is Double Wood TUDCA 500mg safe to take daily?

Yes, TUDCA at 500mg daily is within the clinically studied dose range and is generally well tolerated. Double Wood Supplements third-party tests their TUDCA for purity and potency.

Double Wood Supplements TUDCA 500mg: Can Double Wood TUDCA cause digestive issues?

As a bile acid, TUDCA can occasionally cause loose stools or mild digestive changes, especially at higher doses. Starting with one capsule (250mg) and increasing to the full 2-capsule serving can help minimize initial digestive effects.

Double Wood Supplements TUDCA 500mg: Is Double Wood TUDCA safe to take with other supplements?

TUDCA generally pairs well with other liver-supportive supplements like NAC and milk thistle. However, if you are taking prescription bile acid medications or cholesterol drugs, consult your doctor before adding TUDCA.

Double Wood Supplements TUDCA 500mg: Can Double Wood TUDCA affect cholesterol levels?

Bile acids play a role in cholesterol metabolism, and TUDCA may influence cholesterol levels. If you are taking cholesterol-lowering medications like statins, discuss TUDCA supplementation with your healthcare provider.

Double Wood Supplements TUDCA 500mg: Is Double Wood TUDCA safe for people with gallstones?

TUDCA promotes bile flow, which could theoretically affect existing gallstones. If you have known gallstones or gallbladder disease, consult your healthcare provider before starting TUDCA supplementation.

Double Wood Supplements TUDCA 500mg: How many Double Wood TUDCA capsules should I take daily?

The recommended serving is 2 capsules (500mg total). For a lower maintenance dose, some users take 1 capsule (250mg) daily. Start with 1 capsule and work up to 2 if desired.

Double Wood Supplements TUDCA 500mg: Should I take Double Wood TUDCA with food?

Yes, taking TUDCA with meals is recommended. Since TUDCA is a bile acid involved in digestion, taking it with food aligns with its natural physiological role and may improve tolerance.

Double Wood Supplements TUDCA 500mg: Can I take both capsules of Double Wood TUDCA at once?

Yes, both capsules can be taken together with a meal for the full 500mg serving. Alternatively, you can split them into 1 capsule with breakfast and 1 with dinner for more consistent levels throughout the day.

Double Wood Supplements TUDCA 500mg: How long should I take Double Wood TUDCA?

TUDCA can be taken as an ongoing supplement for liver and bile flow support. There is no established maximum duration. Many users take it continuously, while others use it for targeted periods of liver support.

Double Wood Supplements TUDCA 500mg: Is 500mg of TUDCA too much for a daily dose?

No, 500mg is a commonly used dose for targeted liver support. Clinical research has used doses from 250mg up to 1500mg daily. The 500mg dose is in the moderate range and appropriate for active liver support without being excessive.

Double Wood Supplements TUDCA 500mg: What is the active ingredient in Double Wood TUDCA?

The active ingredient is tauroursodeoxycholic acid (TUDCA), a water-soluble bile acid. Each capsule contains 250mg of TUDCA, with the standard serving being 2 capsules (500mg total).

Double Wood Supplements TUDCA 500mg: How is Double Wood TUDCA manufactured?

TUDCA is produced through chemical conjugation of taurine with ursodeoxycholic acid. Double Wood sources their TUDCA from reputable manufacturers and verifies potency through third-party testing.

Double Wood Supplements TUDCA 500mg: Does Double Wood TUDCA contain any additional ingredients?

The formula is straightforward with TUDCA as the sole active ingredient. Inactive ingredients include the capsule shell and minimal excipients needed for proper manufacturing. It does not contain additional herbs or cofactors.

Double Wood Supplements TUDCA 500mg: Is Double Wood TUDCA vegan-friendly?

Yes, Double Wood labels their TUDCA as vegan. The TUDCA is synthetically produced (not animal-derived) and the capsules are plant-based.

Double Wood Supplements TUDCA 500mg: What is the difference between TUDCA and regular bile supplements?

TUDCA is a specific bile acid (tauroursodeoxycholic acid) with unique cellular protective properties. Regular bile supplements often contain ox bile or mixed bile acids. TUDCA has distinct anti-apoptotic and ER stress-reducing effects not found in general bile supplements.

Double Wood Supplements TUDCA 500mg: How effective is Double Wood TUDCA at 500mg?

The 500mg dose is commonly used for active liver support and is within the range shown to improve liver enzyme markers in clinical studies. This dose provides meaningful bile flow support and cellular protection.

Double Wood Supplements TUDCA 500mg: Can Double Wood TUDCA help with liver enzyme levels?

Research suggests TUDCA can help improve elevated liver enzymes (ALT, AST, GGT) with consistent use at adequate doses. The 500mg serving from Double Wood is within the therapeutic range used in clinical studies.

Double Wood Supplements TUDCA 500mg: Is Double Wood TUDCA effective for bodybuilders and athletes?

TUDCA has become popular among bodybuilders and athletes for liver support during periods of increased liver stress. The 500mg dose per serving is the amount most commonly recommended in athletic communities for liver protection.

Double Wood Supplements TUDCA 500mg: How does Double Wood TUDCA compare to Nutricost TUDCA?

Double Wood provides 500mg per serving (2 capsules) versus Nutricost's 250mg per capsule. Both are third-party tested. Double Wood is better for those wanting a higher dose, while Nutricost offers more flexible low-dose options.

Double Wood Supplements TUDCA 500mg: How many capsules come in a bottle of Double Wood TUDCA?

Each bottle contains 60 capsules. At the recommended 2-capsule serving (500mg), this provides 30 servings or a 1-month supply. At 1 capsule daily, the bottle lasts 2 months.

Double Wood Supplements TUDCA 500mg: What size are Double Wood TUDCA capsules?

The capsules are standard-sized and easy to swallow. At 250mg per capsule, they are not oversized. Two capsules make up the full 500mg serving.

Double Wood Supplements TUDCA 500mg: How should I store Double Wood TUDCA?

Store in a cool, dry place away from direct sunlight. Keep the bottle tightly sealed between uses. TUDCA is stable at room temperature but should be kept away from excessive heat and moisture.

Best TUDCA Supplements (2026)

· Updated April 2026

Lab Tested, Evidence Ranked

Supplement Science Editorial Team·Evidence-Based Supplement Research

Published Mar 11, 2026·Reviewed Apr 24, 2026

2,400+Clinical Studies Cited

3TUDCA (Tauroursodeoxycholic Acid) products evaluated

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Our Verdict

The best TUDCA supplement delivers 250-500mg of tauroursodeoxycholic acid per serving with third-party testing for purity, as TUDCA is a premium bile acid where manufacturing quality varies significantly.

Best By Category

#1Best Overall / Best Value

Nutricost TUDCA 250mg

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#2Best High-Dose

Double Wood Supplements TUDCA 500mg

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#3Best Combination Formula

Thorne Liver Cleanse

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#1 Top Pick

Staff Pick

TUDCA 250mg

Nutricost

5,738 Amazon reviews

8.8/10

4.6

Delivers 250mg TUDCA per capsule — the standard starting dose for liver and bile flow support. Nutricost provides third-party tested supplements at competitive prices. Clean formula with minimal excipients. 60 capsules per bottle allows flexible dosing (1-2 capsules daily).

IngredientTauroursodeoxycholic Acid (TUDCA)

Dose250mg TUDCA per capsule

FormCapsule

TestingThird-Party Tested

250mg TUDCA per capsuleClinical range: 250-1500mg daily

Therapeutic dose

$0.41/serving$24.89 · 60 Capsules

Pros

Affordable TUDCA at $0.33/serving
Third-party tested
Flexible 250mg dosing

Cons

Lower 250mg dose per capsule
Value brand positioning

Gluten-freeNon-GMO

Buy Nowon Amazon

Read full review →

The best TUDCA supplement provides 250-500mg per serving with verified purity and third-party testing.

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We evaluated TUDCA (tauroursodeoxycholic acid) supplements based on dose, purity verification, third-party testing, brand reputation, and value. TUDCA is a premium supplement where quality assurance is critical due to complex manufacturing.

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Quick Comparison

#1Nutricost TUDCA 250mg

8.8/10

Nutricost

#1 Top Pick

5,738 Amazon reviews

Best for: Standard-dose pure TUDCA (250mg) at the best per-serving value

Tauroursodeoxycholic Acid (TUDCA) · 250mg TUDCA per capsule

Capsule · Third-Party Tested

$24.89

$0.41/serving

Buy Nowon Amazon

#2Double Wood Supplements TUDCA 500mg

8.6/10

Double Wood Supplements

5,197 Amazon reviews

Best for: High-dose pure TUDCA (500mg) for targeted liver support

Tauroursodeoxycholic Acid (TUDCA) · 500mg TUDCA per serving (2 capsules)

Capsule · Third-Party Tested

$24.93

$0.42/serving

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#3Thorne Liver Cleanse

9/10

THORNE

1,884 Amazon reviews

Best for: Comprehensive liver support formula featuring TUDCA

TUDCA + Milk Thistle (Siliphos) + N-Acetyl Cysteine · TUDCA + silymarin phytosome + NAC per serving

Capsule · NSFNSF Certified for Sport

$26.60

$0.89/serving

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#	Product	Best For	Ingredient & Dose	Form & Testing	Price	Rating
1	Nutricost TUDCA 250mg #1 Top Pick 5,738 Amazon reviews	Standard-dose pure TUDCA (250mg) at the best per-serving value	Tauroursodeoxycholic Acid (TUDCA) 250mg TUDCA per capsule	Capsule 60 Capsules Third-Party Tested	$24.89 $0.41/serving	8.8/10	Buy Nowon Amazon
2	Double Wood Supplements TUDCA 500mg 5,197 Amazon reviews	High-dose pure TUDCA (500mg) for targeted liver support	Tauroursodeoxycholic Acid (TUDCA) 500mg TUDCA per serving (2 capsules)	Capsule 60 Capsules Third-Party Tested	$24.93 $0.42/serving	8.6/10	Buy Nowon Amazon
3	Thorne Liver Cleanse 1,884 Amazon reviews	Comprehensive liver support formula featuring TUDCA	TUDCA + Milk Thistle (Siliphos) + N-Acetyl Cysteine TUDCA + silymarin phytosome + NAC per serving	Capsule 60 Capsules NSFNSF Certified for Sport	$26.60 $0.89/serving	9/10	Buy Nowon Amazon

How We Chose These Products

We scored every contender on the 5weighted criteria below. Evidence quality and third-party verification carry the most weight; value, clean-label formulation, and transparency round out the score. Where tradeoffs appear — a higher-evidence form that costs more, a research-grade dose in a product with a heavier price tag, a commodity ingredient at a rock-bottom price — the pick that wins on evidence-grade criteria takes the top slot. Business partnerships never move a product's score, and lower-cost non-affiliate alternatives are included when they meet the same evidence bar.

Purity & Manufacturing

30%

TUDCA is synthesized through a complex process conjugating taurine with ursodeoxycholic acid. Manufacturing quality directly impacts purity. Third-party testing is essential to verify actual TUDCA content.

Dose Adequacy

25%

Clinical studies use 250-1500mg daily depending on the indication. For general liver support: 250-500mg daily. For bile flow support: 500-1000mg daily. Higher doses should be used under medical guidance.

Third-Party Testing

25%

Independent verification of TUDCA identity, potency, and purity. Critical for this category due to the complexity and cost of TUDCA synthesis — adulteration risk is higher than most supplements.

Brand Transparency

10%

Clear sourcing information, manufacturing standards, and Certificate of Analysis availability.

Value

10%

Cost per serving relative to TUDCA dose and verified purity. TUDCA is inherently expensive; very cheap products may indicate quality concerns.

Detailed Reviews

#1 Top Pick

Nutricost Tudca 250mg, 60 Capsules (Tauroursodeoxycholic Acid) - Premium Quality

Nutricost

5,738 Amazon reviews

8.8/10

(5,738)

Gluten-freeNon-GMO

IngredientTauroursodeoxycholic Acid (TUDCA)

Dose250mg TUDCA per capsule

FormCapsule

TestingThird-Party Tested

250mg TUDCA per capsuleClinical range: 250-1500mg daily

Therapeutic dose

$0.41/serving$24.89 · 60 Capsules

Ideal for: Standard-dose pure TUDCA (250mg) at the best per-serving value

Not ideal for: Those needing high-dose TUDCA (500mg+) per capsule.

Pros

Affordable TUDCA at $0.33/serving
Third-party tested
Flexible 250mg dosing
Clean formula

Cons

Lower 250mg dose per capsule
Value brand positioning
Less sourcing transparency
No Certificate of Analysis publicly available

Buy Nowon Amazon

Read full Tauroursodeoxycholic Acid (TUDCA)guide →

TUDCA Bile Salts Liver Support Supplement, 500mg Servings, Liver and Gallbladder Cleanse Supplement (60 Capsules, 250mg) Genuine Bile Acid TUDCA with Strong Bitter Taste by Double Wood

Double Wood Supplements

5,197 Amazon reviews

8.6/10

(5,197)

Gluten-freeNon-GMOVegan

Delivers 500mg TUDCA per 2-capsule serving — the dose most commonly used for targeted liver and bile flow support. Double Wood has built a reputation for nootropics and specialty supplements with third-party testing. Good option for those who want a higher dose without taking multiple products.

IngredientTauroursodeoxycholic Acid (TUDCA)

Dose500mg TUDCA per serving (2 capsules)

FormCapsule

TestingThird-Party Tested

500mg TUDCA per serving (2 capsules)Clinical range: 250-1500mg daily

Therapeutic dose

$0.42/serving$24.93 · 60 Capsules

Ideal for: High-dose pure TUDCA (500mg) for targeted liver support

Not ideal for: Budget shoppers or those needing only a maintenance dose.

Pros

Full 500mg dose per serving
Third-party tested for purity
Established in specialty supplement space
Good for targeted liver support

Cons

Requires 2 capsules per serving
Higher cost ($0.53/serving)
Newer brand
Less sourcing detail

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Read full Tauroursodeoxycholic Acid (TUDCA)guide →

THORNE - Liver Cleanse - Milk Thistle & Berberine Supplement with Burdock & Chicory Extracts - Herbal Blend Supports the Liver’s Natural Detoxification Function* - Third-Party Certified - 60 Capsules

THORNE

1,884 Amazon reviews

9/10

(1,884)

Gluten-freeNon-GMODairy-freeSoy-free

Thorne combines TUDCA with two other premier liver-supportive ingredients: Siliphos (silybin phytosome for enhanced absorption) and NAC (glutathione precursor). NSF Certified for Sport provides the highest level of third-party verification. Thorne is trusted by Mayo Clinic and US Olympic teams. Comprehensive formula addressing multiple liver support pathways.

IngredientTUDCA + Milk Thistle (Siliphos) + N-Acetyl Cysteine

DoseTUDCA + silymarin phytosome + NAC per serving

FormCapsule

TestingNSF Certified for Sport

TUDCA + silymarin phytosome + NAC per servingClinical range: 250-1500mg daily

Blend formula

$0.89/serving$26.60 · 60 Capsules

Ideal for: Comprehensive liver support formula featuring TUDCA

Not ideal for: Those wanting standalone TUDCA or seeking the lowest price.

Pros

NSF Certified for Sport (highest testing standard)
Comprehensive liver formula (TUDCA + Siliphos + NAC)
Trusted by Mayo Clinic
Multiple liver support pathways

Cons

Premium price ($0.72/serving)
Lower TUDCA dose in combo formula
May be excessive for basic support
Requires multiple capsules

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Read full TUDCA + Milk Thistle (Siliphos) + N-Acetyl Cysteineguide →

Pairs Well With

Frequently taken together based on complementary benefits

Dandelion Root

Peak Performance Organic Dandelion Root Capsules

1,500mg per serving (2 capsules)

(395)$0.30/serving

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How to Choose

Why TUDCA Quality Matters More Than Most Supplements

TUDCA is synthesized by conjugating taurine with ursodeoxycholic acid (UDCA) — a process that requires careful chemistry. Low-quality manufacturing can result in products containing mostly UDCA (which is cheaper) rather than true TUDCA. Always choose products with third-party testing that specifically verifies TUDCA content.

TUDCA Dose Guidelines

General liver maintenance: 250mg daily. Targeted liver and bile flow support: 500mg daily. Higher doses (1000-1500mg) are used in clinical research settings and should be supervised by a healthcare provider. Start with 250mg and increase if needed. Take with meals for best tolerance.

Ready to Buy?

Nutricost TUDCA 250mg

8.8/10$0.41/servingBest for: Standard-dose pure TUDCA (250mg) at the best per-serving value

Evidence:Review (2019) · moderate confidence[#1]

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Read Our Full TUDCA (Tauroursodeoxycholic Acid) Research Guide

Evidence level, dosage, side effects, and more →

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Bottom line: Artichoke extract is a well-tolerated choleretic that boosts bile flow and lowers cholesterol. Take 600-1200mg daily for digestive and liver support.

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Bottom line: Phosphatidylcholine repairs hepatocyte membranes and fights fatty liver. Take 900-1800mg polyenylphosphatidylcholine daily for liver membrane support.

Glutathione (Liver Support)Strong

Bottom line: Glutathione is the liver's master detoxifier and antioxidant. Take 500-1000mg liposomal glutathione daily or use NAC as a precursor.

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Bottom line: ALA is a versatile antioxidant that recycles glutathione and reduces liver inflammation. Take 300-600mg R-ALA daily for NAFLD and liver protection.

Related Conditions

Liver Health

Frequently Asked Questions

What is the best TUDCA supplement?

Nutricost TUDCA 250mg offers the best value for general liver support at $0.33/serving. For a comprehensive liver formula, Thorne Liver Cleanse combines TUDCA with Siliphos milk thistle and NAC — with NSF Certified for Sport verification.

How much TUDCA should I take?

For general liver support: 250mg daily. For targeted bile flow and liver protection: 500mg daily. Clinical research uses doses up to 1500mg daily, but higher doses should be used under medical guidance. Start low and increase gradually. Take with meals.

Can TUDCA be taken long-term?

Short-term studies (up to 6 months) show TUDCA is well-tolerated at 250-1,750mg daily. Long-term safety data is limited, so most practitioners recommend cycling — typically 8-12 weeks on followed by a 2-4 week break — for ongoing liver or eye support.

Does TUDCA have side effects?

TUDCA is generally well-tolerated. Common mild side effects include loose stools or mild stomach discomfort, particularly at doses above 1g daily. People with bile duct obstruction or severe gallbladder disease should avoid TUDCA without medical supervision.

Evidence:Review (2019) · moderate confidence[#1]

Continue Reading

Supplement Guide

Milk Thistle (Silymarin)

Bottom line: Milk thistle is the gold-standard herbal hepatoprotectant. Take 420-600mg silymarin daily for liver enzyme reduction and antioxidant protection.

Condition Guide

Liver Health

References

ReviewKusaczuk M (2019). Tauroursodeoxycholate — bile acid with chaperoning activity: molecular and cellular effects and therapeutic perspectives. Cells. DOI PubMed
ReviewVang S, Longley K, Steer CJ, Low WC (2014). The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases. Global Advances in Health and Medicine. DOI PubMed