Prevalence: 9.2 million US adults (3.9% of the population) — Arthritis Foundation / NHANES data
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The most evidence-backed supplements for gout are tart cherry extract (which lowers uric acid and reduces flare risk by 35-45%), vitamin C (500mg daily shown to reduce uric acid by 0.35 mg/dL), and quercetin (500mg daily inhibits xanthine oxidase activity).
Gout is an inflammatory arthritis caused by the deposition of monosodium urate crystals in joints, most commonly the big toe. It affects approximately 9.2 million adults in the United States and is strongly associated with elevated serum uric acid levels. Several supplements have demonstrated urate-lowering or anti-inflammatory properties in clinical studies.
| # | Supplement | Typical Dose | Evidence |
|---|---|---|---|
| 1 | Tart Cherry Extract | 480mg extract or 8 oz juice twice daily | Moderate |
| 2 | Vitamin C | 500mg daily | Strong |
| 3 | Quercetin | 500mg daily | Emerging |
| 4 | Omega-3 Fatty Acids | 1-2g EPA+DHA daily | Moderate |
| 5 | Turmeric / Curcumin | 500mg curcumin twice daily | Emerging |
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Nature Made Vitamin C 1000mg
Nature Made
Thorne Quercetin Phytosome
Thorne
Nordic Naturals Ultimate Omega
Nordic Naturals
Thorne Meriva-SF Curcumin Phytosome
Thorne
Yes. A prospective study of 633 gout patients published in Arthritis & Rheumatism found that cherry intake (whole fruit or extract) over a two-day period was associated with a 35% lower risk of gout attacks. Tart cherry contains anthocyanins that inhibit inflammatory pathways and may modestly reduce uric acid levels.
A meta-analysis of 13 randomized controlled trials found that vitamin C supplementation (median dose 500mg/day) significantly reduced serum uric acid by 0.35 mg/dL. Vitamin C enhances renal uric acid excretion. While helpful for mild hyperuricemia, it should not replace urate-lowering therapy prescribed for diagnosed gout.
Omega-3 fatty acids (1-2g EPA+DHA) and curcumin (500mg twice daily) both reduce pro-inflammatory cytokines involved in gout flares. Tart cherry extract also provides acute anti-inflammatory benefits. These can complement, but should not replace, physician-directed flare management.
Quercetin inhibits xanthine oxidase, the same enzyme targeted by the prescription drug allopurinol, though with weaker potency. A small RCT in hyperuricemic men showed 500mg daily reduced uric acid levels. Evidence is still emerging, but quercetin may be a useful adjunct for mild hyperuricemia.